Skeletal muscle constitutes∼ 40% of body mass and has the capacity to play a major role as
thermogenic, metabolic, and endocrine organ. In addition to shivering, muscle also …

In healthy muscle, the rapid release of calcium ions (Ca2+) with excitation–contraction (EC)
coupling, results in elevations in Ca2+ concentrations which can exceed 10-fold that of …

Abstract White Striping and Wooden Breast (WS/WB) are abnormalities increasingly
occurring in the fillets of high breast yield and growth rate chicken hybrids. These defects …

Sarcolipin (SLN) is a small regulatory protein that inhibits the sarco (endo) plasmic reticulum
Ca2+-ATPase (SERCA) pump. When bound to SERCA, SLN reduces the apparent Ca2+ …

Neuronatin (NNAT) is a transmembrane protein in the endoplasmic reticulum involved in
metabolic regulation. It shares sequence homology with sarcolipin (SLN), which negatively …

A decrease in skeletal muscle contractile activity or its complete cessation (muscle
unloading or disuse) leads to muscle fibers' atrophy and to alterations in muscle …

It is well established that microgravity exposure causes significant muscle weakness and
atrophy via muscle unloading. On Earth, muscle unloading leads to a disproportionate loss …

Obesity is increasing at an alarming rate, both in adults and adolescents, across the globe
due to increased consumption of caloric rich diet. Obesity and its associated complications …

Glycogen synthase kinase 3 (GSK3) slows myogenic differentiation and myoblast fusion
partly by inhibiting the Wnt/β-catenin signaling pathway. Lithium, a common medication for …

We are currently facing an “obesity epidemic” worldwide. Promoting inefficient metabolism in
muscle represents a potential treatment for obesity and its complications. Sarco (endo) …