[HTML][HTML] Persistent enterovirus infection: little deletions, long infections

NM Chapman - Vaccines, 2022 - mdpi.com
Enteroviruses have now been shown to persist in cell cultures and in vivo by a novel
mechanism involving the deletion of varying amounts of the 5′ terminal genomic region …

[HTML][HTML] Molecular frustration: a hypothesis for regulation of viral infections

R Twarock, GJ Towers, PG Stockley - Trends in Microbiology, 2023 - cell.com
The recent revolution in imaging techniques and results from RNA footprinting in situ reveal
how the bacteriophage MS2 genome regulates both particle assembly and genome release …

[HTML][HTML] Membrane-assisted assembly and selective secretory autophagy of enteroviruses

S Dahmane, A Kerviel, DR Morado, K Shankar… - Nature …, 2022 - nature.com
Enteroviruses are non-enveloped positive-sense RNA viruses that cause diverse diseases
in humans. Their rapid multiplication depends on remodeling of cytoplasmic membranes for …

[HTML][HTML] Cryo-electron microscopy and image classification reveal the existence and structure of the coxsackievirus A6 virion

CR Büttner, R Spurný, T Füzik, P Plevka - Communications Biology, 2022 - nature.com
Abstract Coxsackievirus A6 (CV-A6) has recently overtaken enterovirus A71 and CV-A16 as
the primary causative agent of hand, foot, and mouth disease worldwide. Virions of CV-A6 …

Novel strategies for the development of hand, foot, and mouth disease vaccines and antiviral therapies

CY Fang, CC Liu - Expert Opinion on Drug Discovery, 2022 - Taylor & Francis
Introduction Hand, foot, and mouth disease (HFMD) poses a great threat to young children in
the Asia-Pacific region. HFMD is usually caused by enterovirus A, and infection with …

[HTML][HTML] Rhinovirus inhibitors: Including a new target, the viral RNA

A Real-Hohn, D Blaas - Viruses, 2021 - mdpi.com
Rhinoviruses (RVs) are the main cause of recurrent infections with rather mild symptoms
characteristic of the common cold. Nevertheless, RVs give rise to enormous numbers of …

[HTML][HTML] CryoVirusDB: a labeled cryo-EM image dataset for AI-driven virus particle picking

R Gyawali, A Dhakal, L Wang, J Cheng - bioRxiv, 2023 - ncbi.nlm.nih.gov
With the advancements in instrumentation, image processing algorithms, and computational
capabilities, single-particle electron cryo-microscopy (cryo-EM) has achieved nearly atomic …

Inactivation Kinetics and Replication Cycle Inhibition of Coxsackievirus B5 by Free Chlorine

W Cong, A Pike, K Gonçalves, JL Shisler… - Environmental …, 2023 - ACS Publications
The kinetics of coxsackievirus serotype B5 (CVB5) inactivation with free chlorine is
characterized over a range of pH and temperature relevant to drinking water treatment with …

Asymmetry in icosahedral viruses

J Jose, SL Hafenstein - Current Opinion in Virology, 2022 - Elsevier
Asymmetric structural elements are typically not readily visualized in icosahedral viruses that
have other obvious symmetrical features and most asymmetry has gone unresolved for …

[HTML][HTML] Genome-regulated assembly of a ssRNA virus may also prepare it for infection

R Chandler-Bostock, RJ Bingham, S Clark… - Journal of Molecular …, 2022 - Elsevier
Many single-stranded, positive-sense RNA viruses regulate assembly of their infectious
virions by forming multiple, cognate coat protein (CP)-genome contacts at sites termed …