The development of the sequencing technologies allowed the generation of huge amounts
of molecular data from a single cancer specimen, allowing the clinical oncology to enter the …

The identification of individual or clusters of predictive genetic alterations might help in
defining the outcome of cancer treatment, allowing for the stratification of patients into …

Background: Drug repositioning is a new research area in drug development. It aims to
discover novel therapeutic uses of existing drugs. It could accelerate the process of …

Background: The side effects of drugs are not only harmful to humans but also the major
reasons for withdrawing approved drugs, bringing greater risks for pharmaceutical …

Metabolic pathway is an important type of biological pathways. It produces essential
molecules and energies to maintain the life of living organisms. Each metabolic pathway …

Background Recently high-throughput technologies have been massively used alongside
clinical tests to study various types of cancer. Data generated in such large-scale studies are …

Multi-omics data are increasingly being gathered for investigations of complex diseases
such as cancer. However, high dimensionality, small sample size, and heterogeneity of …

Background: Identification of drug-target interaction is essential in drug discovery. It is
beneficial to predict unexpected therapeutic or adverse side effects of drugs. To date …

Background The availability of high-throughput omics datasets from large patient cohorts
has allowed the development of methods that aim at predicting patient clinical outcomes …

The human zinc finger (C2H2-type) protein ZNF750 is a transcription factor regulated by p63
that plays a critical role in epithelial tissues homoeostasis, as well as being involved in the …