[HTML][HTML] Meta-analysis of ABCG2 and ABCB1 polymorphisms with sunitinib-induced toxicity and efficacy in renal cell carcinoma
F Sun, Z Chen, P Yao, B Weng, Z Liu… - Frontiers in …, 2021 - frontiersin.org
Background: ABCG2 and ABCB1 are genes related to the pharmacokinetics of sunitinib and
have been associated with its toxicity and efficacy. However, the results have been …
have been associated with its toxicity and efficacy. However, the results have been …
Cognitive performance, neuropsychiatric symptoms, and cerebrospinal fluid viral control following programmatic switch from efavirenz-based to dolutegravir-based …
Background Both efavirenz and dolutegravir have been associated with neuropsychiatric
side-effects and cognitive impairment. Furthermore, cerebrospinal fluid (CSF) HIV RNA …
side-effects and cognitive impairment. Furthermore, cerebrospinal fluid (CSF) HIV RNA …
Activity Variations of CYP2B6 Determine the Metabolic Stratification of Efavirenz
X Li, Q Liu, X Xu, J Wang, Y Zhong, L Jin… - Chemical Research …, 2024 - ACS Publications
Purpose: To investigate the effects of hepatic enzyme activity variations and CYP2B6 gene
polymorphisms on the in vivo and in vitro metabolism of efavirenz. Main methods: In vitro …
polymorphisms on the in vivo and in vitro metabolism of efavirenz. Main methods: In vitro …
One Step Ahead in Realizing Pharmacogenetics in Low-and Middle-Income Countries: What Should We Do?
Y Ausi, MI Barliana, MJ Postma… - Journal of …, 2024 - Taylor & Francis
Pharmacogenetics is a promising approach in future personalized medicine. This field holds
excellent prospects for healthcare quality acceleration. It promotes the transition to the …
excellent prospects for healthcare quality acceleration. It promotes the transition to the …
[HTML][HTML] Functional significance of CYP2B6 gene rare allelic variants identified in Japanese individuals
S Yamazaki, E Hishinuma, Y Suzuki, A Ueda… - Biochemical …, 2024 - Elsevier
Abstract Cytochrome P450 2B6 (CYP2B6) catalyzes the metabolism of many drugs,
including efavirenz and propofol. Genetic polymorphisms in CYP2B6 alter its enzymatic …
including efavirenz and propofol. Genetic polymorphisms in CYP2B6 alter its enzymatic …
Estimation of the benefit from pre‐emptive genotyping based on the nationwide cohort data in South Korea
KY Huh, S Hwang, JY Na, KS Yu… - Clinical and …, 2024 - Wiley Online Library
Genetic variants affect drug responses, making pre‐emptive genotyping crucial for averting
serious adverse events (SAEs) and treatment failure. However, assessing the benefits of pre …
serious adverse events (SAEs) and treatment failure. However, assessing the benefits of pre …
[HTML][HTML] Effects of CYP2B6 polymorphisms on plasma nevirapine concentrations: a systematic review and meta-analysis
Cytochrome P450 (CYP) is involved in the metabolism of nevirapine (NVP); especially,
CYP2B6 has been known to be one of the main enzymes involved in NVP metabolism. The …
CYP2B6 has been known to be one of the main enzymes involved in NVP metabolism. The …
[HTML][HTML] Adverse events in Chinese human immunodeficiency virus (HIV) patients receiving first line antiretroviral therapy
L Dai, B Su, A Liu, H Zhang, H Wu, T Zhang… - BMC infectious …, 2020 - Springer
Background Although the global human immunodeficiency virus (HIV) epidemic has
improved significantly due to antiretroviral treatment (ART), ART-related adverse events …
improved significantly due to antiretroviral treatment (ART), ART-related adverse events …
Meta-analysis of the associations of IMPDH and UGT1A9 polymorphisms with rejection in kidney transplant recipients taking mycophenolic acid
L Cheng, P Yao, B Weng, M Yang, Q Wang - European Journal of Clinical …, 2022 - Springer
Purpose To investigate the associations of IMPDH and UGT1A9 polymorphisms with
rejection in kidney transplant recipients taking mycophenolic acid (MPA). Methods PubMed …
rejection in kidney transplant recipients taking mycophenolic acid (MPA). Methods PubMed …