PharmVar GeneFocus: CYP2B6

Z Desta, A El‐Boraie, L Gong… - Clinical …, 2021 - Wiley Online Library
The Pharmacogene Variation Consortium (PharmVar) catalogs star (*) allele nomenclature
for the polymorphic human CYP2B6 gene. Genetic variation within the CYP2B6 gene locus …

[HTML][HTML] Meta-analysis of ABCG2 and ABCB1 polymorphisms with sunitinib-induced toxicity and efficacy in renal cell carcinoma

F Sun, Z Chen, P Yao, B Weng, Z Liu… - Frontiers in …, 2021 - frontiersin.org
Background: ABCG2 and ABCB1 are genes related to the pharmacokinetics of sunitinib and
have been associated with its toxicity and efficacy. However, the results have been …

Cognitive performance, neuropsychiatric symptoms, and cerebrospinal fluid viral control following programmatic switch from efavirenz-based to dolutegravir-based …

S Nightingale, AJ Dreyer, KGF Thomas, G van Zyl… - The Lancet …, 2024 - thelancet.com
Background Both efavirenz and dolutegravir have been associated with neuropsychiatric
side-effects and cognitive impairment. Furthermore, cerebrospinal fluid (CSF) HIV RNA …

Activity Variations of CYP2B6 Determine the Metabolic Stratification of Efavirenz

X Li, Q Liu, X Xu, J Wang, Y Zhong, L Jin… - Chemical Research …, 2024 - ACS Publications
Purpose: To investigate the effects of hepatic enzyme activity variations and CYP2B6 gene
polymorphisms on the in vivo and in vitro metabolism of efavirenz. Main methods: In vitro …

One Step Ahead in Realizing Pharmacogenetics in Low-and Middle-Income Countries: What Should We Do?

Y Ausi, MI Barliana, MJ Postma… - Journal of …, 2024 - Taylor & Francis
Pharmacogenetics is a promising approach in future personalized medicine. This field holds
excellent prospects for healthcare quality acceleration. It promotes the transition to the …

[HTML][HTML] Functional significance of CYP2B6 gene rare allelic variants identified in Japanese individuals

S Yamazaki, E Hishinuma, Y Suzuki, A Ueda… - Biochemical …, 2024 - Elsevier
Abstract Cytochrome P450 2B6 (CYP2B6) catalyzes the metabolism of many drugs,
including efavirenz and propofol. Genetic polymorphisms in CYP2B6 alter its enzymatic …

Estimation of the benefit from pre‐emptive genotyping based on the nationwide cohort data in South Korea

KY Huh, S Hwang, JY Na, KS Yu… - Clinical and …, 2024 - Wiley Online Library
Genetic variants affect drug responses, making pre‐emptive genotyping crucial for averting
serious adverse events (SAEs) and treatment failure. However, assessing the benefits of pre …

[HTML][HTML] Effects of CYP2B6 polymorphisms on plasma nevirapine concentrations: a systematic review and meta-analysis

HY Yoon, YA Cho, J Yee, HS Gwak - Scientific Reports, 2020 - nature.com
Cytochrome P450 (CYP) is involved in the metabolism of nevirapine (NVP); especially,
CYP2B6 has been known to be one of the main enzymes involved in NVP metabolism. The …

[HTML][HTML] Adverse events in Chinese human immunodeficiency virus (HIV) patients receiving first line antiretroviral therapy

L Dai, B Su, A Liu, H Zhang, H Wu, T Zhang… - BMC infectious …, 2020 - Springer
Background Although the global human immunodeficiency virus (HIV) epidemic has
improved significantly due to antiretroviral treatment (ART), ART-related adverse events …

Meta-analysis of the associations of IMPDH and UGT1A9 polymorphisms with rejection in kidney transplant recipients taking mycophenolic acid

L Cheng, P Yao, B Weng, M Yang, Q Wang - European Journal of Clinical …, 2022 - Springer
Purpose To investigate the associations of IMPDH and UGT1A9 polymorphisms with
rejection in kidney transplant recipients taking mycophenolic acid (MPA). Methods PubMed …