SARS-CoV-2 NSP12 associates with TRiC and the P323L substitution acts as a host adaption

M Alruwaili, S Armstrong, T Prince, M Erdmann… - Journal of …, 2023 - Am Soc Microbiol
ABSTRACT SARS-CoV-2 emerged in the human population in late 2019, and human-to-
human transmission has dominated the evolutionary landscape and driven the selection of …

[HTML][HTML] Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever

D Kotliar, S Raju, S Tabrizi, I Odia, A Goba… - Nature …, 2024 - nature.com
Infection with Lassa virus (LASV) can cause Lassa fever, a haemorrhagic illness with an
estimated fatality rate of 29.7%, but causes no or mild symptoms in many individuals. Here …

Activation of protein kinase receptor (PKR) plays a pro-viral role in mammarenavirus-infected cells

H Witwit, R Khafaji, A Salaniwal, AS Kim… - Journal of …, 2024 - Am Soc Microbiol
Many viruses, including mammarenaviruses, have evolved mechanisms to counteract
different components of the host cell innate immunity, which is required to facilitate robust …

[HTML][HTML] Activation of Protein Kinase R (PKR) Plays a Pro-Viral Role in Mammarenavirus Infected Cells

H Witwit, R Khafaji, A Salaniwal, AS Kim, B Cubitt… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Many viruses, including mammarenaviruses, have evolved mechanisms to counteract
different components of the host cell innate immunity, which is required to facilitate robust …

SARS-CoV-2 NSP12 associates with the TRiC complex and the P323L substitution is a host adaption

M Alruwaili, S Armstrong, T Prince, M Erdmann… - bioRxiv, 2023 - biorxiv.org
SARS-CoV-2 emerged into the human population in late 2019 and human to human
transmission has dominated the evolutionary landscape and driven the selection of different …

Lymphocytic choriomeningitis arenavirus utilises tunnelling nanotube-like intercellular connections for cell-to-cell spread

O Byford, AB Shaw, HN Tse, A Moon-Walker… - bioRxiv, 2023 - biorxiv.org
The Arenaviridae family within the Bunyavirales order of segmented RNA viruses contains
over 50 species grouped into four genera, Antennavirus, Hartmanivirus, Mammarenavirus …

Pioneering genomic technologies and computational tools to study deadly pathogens endemic to low-resource countries

S Raju - 2024 - dash.harvard.edu
The genomics era has given us powerful tools to probe the molecular basis of disease, but
practical constraints have limited their use in certain settings. In particular, underdeveloped …