The scales, mechanisms, and dynamics of the genome architecture
L Lizana, YB Schwartz - Science Advances, 2024 - science.org
Even when split into several chromosomes, DNA molecules that make up our genome are
too long to fit into the cell nuclei unless massively folded. Such folding must accommodate …
too long to fit into the cell nuclei unless massively folded. Such folding must accommodate …
Post-translational modification of lamins: mechanisms and functions
M Zheng, G Jin, Z Zhou - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Lamins are the ancient type V intermediate filament proteins contributing to diverse
biological functions, such as the maintenance of nuclear morphology, stabilization of …
biological functions, such as the maintenance of nuclear morphology, stabilization of …
Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism
EM Pujadas Liwag, X Wei, N Acosta, LM Carter, J Yang… - Genome biology, 2024 - Springer
Background B-type lamins are critical nuclear envelope proteins that interact with the three-
dimensional genomic architecture. However, identifying the direct roles of B-lamins on …
dimensional genomic architecture. However, identifying the direct roles of B-lamins on …
Constricted migration is associated with stable 3D genome structure differences in cancer cells
R Golloshi, C Playter, TF Freeman, P Das, TI Raines… - EMBO …, 2022 - embopress.org
To spread from a localized tumor, metastatic cancer cells must squeeze through
constrictions that cause major nuclear deformations. Since chromosome structure affects …
constrictions that cause major nuclear deformations. Since chromosome structure affects …
[HTML][HTML] Liquid-like chromatin in the cell: What can we learn from imaging and computational modeling?
Chromatin in eukaryotic cells is a negatively charged long polymer consisting of DNA,
histones, and various associated proteins. With its highly charged and heterogeneous …
histones, and various associated proteins. With its highly charged and heterogeneous …
Compartmentalization with nuclear landmarks yields random, yet precise, genome organization
The 3D organization of eukaryotic genomes plays an important role in genome function.
While significant progress has been made in deciphering the folding mechanisms of …
While significant progress has been made in deciphering the folding mechanisms of …
A liquid state perspective on dynamics of chromatin compartments
The interior of the eukaryotic cell nucleus has a crowded and heterogeneous environment
packed with chromatin polymers, regulatory proteins, and RNA molecules. Chromatin …
packed with chromatin polymers, regulatory proteins, and RNA molecules. Chromatin …
[HTML][HTML] Multiscale modelling of chromatin organisation: resolving nucleosomes at near-atomistic resolution inside genes
The three-dimensional organisation of the genome modulates biological processes and is,
in turn, transformed by the activity in the nucleus. Not surprisingly, understanding how the …
in turn, transformed by the activity in the nucleus. Not surprisingly, understanding how the …
Phase separation and correlated motions in motorized genome
The human genome is arranged in the cell nucleus nonrandomly, and phase separation has
been proposed as an important driving force for genome organization. However, the cell …
been proposed as an important driving force for genome organization. However, the cell …
Transcriptional enhancers at 40: evolution of a viral DNA element to nuclear architectural structures
SJ Nair, T Suter, S Wang, L Yang, F Yang… - Trends in Genetics, 2022 - cell.com
Gene regulation by transcriptional enhancers is the dominant mechanism driving cell type-
and signal-specific transcriptional diversity in metazoans. However, over four decades since …
and signal-specific transcriptional diversity in metazoans. However, over four decades since …