Variant surface antigens of Plasmodium falciparum and their roles in severe malaria

M Wahlgren, S Goel, RR Akhouri - Nature Reviews Microbiology, 2017 - nature.com
Proliferation and differentiation inside erythrocytes are important steps in the life cycle of
Plasmodium spp. To achieve these, the parasites export polypeptides to the surface of …

Malaria in pregnancy: pathogenesis and immunity

SJ Rogerson, L Hviid, PE Duffy, RFG Leke… - The Lancet infectious …, 2007 - thelancet.com
Understanding of the biological basis for susceptibility to malaria in pregnancy was recently
advanced by the discovery that erythrocytes infected with Plasmodium falciparum …

[HTML][HTML] Malaria in pregnancy: linking immunity and pathogenesis to prevention

SJ Rogerson, V Mwapasa… - Defining and Defeating …, 2007 - ncbi.nlm.nih.gov
Pregnant women are susceptible to malaria during pregnancy. Plasmodium falciparum,
which sequesters in the placenta, causes the greatest disease, contributing significantly to …

Cryo-electron microscopy of IgM-VAR2CSA complex reveals IgM inhibits binding of Plasmodium falciparum to Chondroitin Sulfate A

RR Akhouri, S Goel, U Skoglund - Nature Communications, 2023 - nature.com
Placental malaria is caused by Plasmodium falciparum-infected erythrocytes (IEs) adhering
to chondroitin sulfate proteoglycans in placenta via VAR2CSA-type PfEMP1. Human …

Pregnancy Outcome and Placenta Pathology in Plasmodium berghei ANKA Infected Mice Reproduce the Pathogenesis of Severe Malaria in Pregnant Women

R Neres, CRF Marinho, LA Gonçalves, MB Catarino… - PloS one, 2008 - journals.plos.org
Pregnancy-associated malaria (PAM) is expressed in a range of clinical complications that
include increased disease severity in pregnant women, decreased fetal viability, intra …

Evasion of immunity to Plasmodium falciparum malaria by IgM masking of protective IgG epitopes in infected erythrocyte surface-exposed PfEMP1

L Barfod, MB Dalgaard, ST Pleman… - Proceedings of the …, 2011 - National Acad Sciences
Plasmodium falciparum malaria is a major cause of mortality and severe morbidity. Its
virulence is related to the parasite's ability to evade host immunity through clonal antigenic …

Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M

C Ji, H Shen, C Su, Y Li, S Chen, TH Sharp… - Nature …, 2023 - nature.com
Plasmodium falciparum causes the most severe malaria in humans. Immunoglobulin M
(IgM) serves as the first line of humoral defense against infection and potently activates the …

Endemic Burkitt's lymphoma as a polymicrobial disease: new insights on the interaction between Plasmodium falciparum and Epstein–Barr virus

A Chene, D Donati, J Orem, A Björkman… - Seminars in cancer …, 2009 - Elsevier
Despite the well-established relationship between endemic Plasmodium falciparum malaria
and Epstein–Barr virus (EBV) infection in the genesis of endemic Burkitt's lymphoma (eBL) …

Plasmodium in the placenta: parasites, parity, protection, prevention and possibly preeclampsia

PE Duffy - Parasitology, 2007 - cambridge.org
The epidemiology of pregnancy malaria infection and disease is complex but reflects
underlying interactions between the Plasmodium falciparum parasite, the mother, and the …

Human pregnancy‐associated malaria‐specific B cells target polymorphic, conformational epitopes in VAR2CSA: This article became available OnlineOpen after it …

L Barfod, NL Bernasconi, M Dahlbäck… - Molecular …, 2007 - Wiley Online Library
Pregnancy‐associated malaria (PAM) is caused by Plasmodium falciparum‐infected
erythrocytes (IEs) that bind to chondroitin sulphate A (CSA) in the placenta by PAM …