Approximately two of every five people will develop cancer in their lifetime. Dietary
modifications are one of the most promising lifestyle changes that can adjust the risk of …

Abstract The CellSearch® system (CS) enables standardized enrichment and enumeration
of circulating tumor cells (CTCs) that are repeatedly assessable via non-invasive “liquid …

The key characteristics (KC) of human carcinogens provide a uniform approach to
evaluating mechanistic evidence in cancer hazard identification. Refinements to the …

In recent years, there have been significant advancements in the nanotechnology for cancer
therapy. Even though molybdenum disulphide (MoS2)-based nanocomposites …

CYP17A1 is an enzyme that plays a major role in steroidogenesis and is critically involved in
the biosynthesis of steroid hormones. Therefore, it remains an attractive target in several …

Androgens, the predominant male sex hormones, drive the development and maintenance
of male characteristics by binding to androgen receptor (AR). As androgens are systemically …

Representative in vitro model systems that accurately model response to therapy and allow
the identification of new targets are important for improving our treatment of prostate cancer …

Prostate cancer (PCa) is a malignant disorder of prostate gland being asymptomatic in early
stages and high metastatic potential in advanced stages. The chemotherapy and surgical …

Cancer cells proliferate, differentiate and migrate by repurposing physiological signalling
mechanisms. In particular, altered calcium signalling is emerging as one of the most …

Prostate cancer (PCa) is the most common non-cutaneous cancer in men in Europe and is
predicted to exhibit declining mortality in the European Union (EU) due to various recent …