Sources of vascular nitric oxide and reactive oxygen species and their regulation
J Tejero, S Shiva, MT Gladwin - Physiological reviews, 2019 - journals.physiology.org
Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …
Clinical update: cardiovascular disease in diabetes mellitus: atherosclerotic cardiovascular disease and heart failure in type 2 diabetes mellitus–mechanisms …
Cardiovascular disease remains the principal cause of death and disability among patients
with diabetes mellitus. Diabetes mellitus exacerbates mechanisms underlying …
with diabetes mellitus. Diabetes mellitus exacerbates mechanisms underlying …
Cardiovascular actions of insulin
R Muniyappa, M Montagnani, KK Koh… - Endocrine …, 2007 - academic.oup.com
Insulin has important vascular actions to stimulate production of nitric oxide from
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and …
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and …
[HTML][HTML] Positive and negative regulation of insulin signaling by reactive oxygen and nitrogen species
N Bashan, J Kovsan, I Kachko… - Physiological …, 2009 - journals.physiology.org
Regulated production of reactive oxygen species (ROS)/reactive nitrogen species (RNS)
adequately balanced by antioxidant systems is a prerequisite for the participation of these …
adequately balanced by antioxidant systems is a prerequisite for the participation of these …
The role of nitric oxide in pre-synaptic plasticity and homeostasis
Since the observation that nitric oxide (NO) can act as an intercellular messenger in the
brain, the past 25 years have witnessed the steady accumulation of evidence that it acts pre …
brain, the past 25 years have witnessed the steady accumulation of evidence that it acts pre …
Tetrahydrobiopterin in cardiovascular health and disease
JK Bendall, G Douglas, E McNeill… - Antioxidants & redox …, 2014 - liebertpub.com
Tetrahydrobiopterin (BH4) functions as a cofactor for several important enzyme systems, and
considerable evidence implicates BH4 as a key regulator of endothelial nitric oxide synthase …
considerable evidence implicates BH4 as a key regulator of endothelial nitric oxide synthase …
Vascular nitric oxide resistance in type 2 diabetes
Vascular nitric oxide (NO•) resistance, manifested by an impaired vasodilator function of NO•
in both the macro-and microvessels, is a common state in type 2 diabetes (T2D) associated …
in both the macro-and microvessels, is a common state in type 2 diabetes (T2D) associated …
Neuronal nitric oxide synthase in vascular physiology and diseases
ED Costa, BA Rezende, SF Cortes… - Frontiers in physiology, 2016 - frontiersin.org
The family of nitric oxide synthases (NOS) has significant importance in various
physiological mechanisms and is also involved in many pathological processes. Three NOS …
physiological mechanisms and is also involved in many pathological processes. Three NOS …
Cyclic stretch, reactive oxygen species, and vascular remodeling
KG Birukov - Antioxidants & redox signaling, 2009 - liebertpub.com
Blood vessels respond to changes in mechanical load from circulating blood in the form of
shear stress and mechanical strain as the result of heart propulsions by changes in …
shear stress and mechanical strain as the result of heart propulsions by changes in …
Claudin-4 expression decreases invasiveness and metastatic potential of pancreatic cancer
Claudin-4 has been identified as an integral constituent of tight junctions and has been
found to be highly expressed in pancreatic cancer. The aim of the present study was to …
found to be highly expressed in pancreatic cancer. The aim of the present study was to …