Biology and therapeutic potential of interleukin-10

M Saraiva, P Vieira, A O'garra - Journal of Experimental Medicine, 2019 - rupress.org
The cytokine IL-10 is a key anti-inflammatory mediator ensuring protection of a host from
over-exuberant responses to pathogens and microbiota, while playing important roles in …

[HTML][HTML] The cytokine network involved in the host immune response to periodontitis

W Pan, Q Wang, Q Chen - International journal of oral science, 2019 - nature.com
Periodontitis is an inflammatory disease involving the destruction of both soft and hard tissue
in the periodontal region. Although dysbiosis of the local microbial community initiates local …

Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China

M Tan, Y Liu, R Zhou, X Deng, F Li, K Liang… - Immunology, 2020 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) is a respiratory disorder caused by the
highly contagious severe acute respiratory syndrome coronavirus 2. The …

Probiotic‐inspired nanomedicine restores intestinal homeostasis in colitis by regulating redox balance, immune responses, and the Gut Microbiome

J Xu, J Xu, T Shi, Y Zhang, F Chen, C Yang… - Advanced …, 2023 - Wiley Online Library
Microbiota‐based therapeutics offer innovative strategies to treat inflammatory bowel
diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the …

[PDF][PDF] IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation

W Ouyang, A O'Garra - Immunity, 2019 - cell.com
Cytokines are among the most important effector and messenger molecules in the immune
system. They profoundly participate in immune responses during infection and inflammation …

[HTML][HTML] Age and age-related diseases: role of inflammation triggers and cytokines

IM Rea, DS Gibson, V McGilligan… - Frontiers in …, 2018 - frontiersin.org
Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

Emerging prospects of exosomes for cancer treatment: from conventional therapy to immunotherapy

GH Nam, Y Choi, GB Kim, S Kim, SA Kim… - Advanced …, 2020 - Wiley Online Library
Exosomes are a class of extracellular vesicles of around 100 nm in diameter that are
secreted by most cells and contain various bioactive molecules reflecting their cellular origin …

[HTML][HTML] The role of cytokines and chemokines in severe acute respiratory syndrome coronavirus 2 infections

RJ Hsu, WC Yu, GR Peng, CH Ye, SY Hu… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in countless
infections and caused millions of deaths since its emergence in 2019. Coronavirus disease …

[HTML][HTML] Macrophage-osteoclast associations: origin, polarization, and subgroups

Y Sun, J Li, X Xie, F Gu, Z Sui, K Zhang… - Frontiers in …, 2021 - frontiersin.org
Cellular associations in the bone microenvironment are involved in modulating the balance
between bone remodeling and resorption, which is necessary for maintaining a normal bone …

The hallmarks of successful anticancer immunotherapy

L Galluzzi, TA Chan, G Kroemer, JD Wolchok… - Science translational …, 2018 - science.org
Immunotherapy is revolutionizing the clinical management of multiple tumors. However, only
a fraction of patients with cancer responds to immunotherapy, and currently available …