Quantitative analysis of thin-section CT of the chest has a growing role in the clinical
evaluation and management of diffuse lung diseases. This heterogeneous group includes …

Chronic obstructive pulmonary disease (COPD) exhibits significant heterogeneity in its
clinical presentation and rate of disease progression among affected individuals, owing at …

Importance While air pollutants at historical levels have been associated with cardiovascular
and respiratory diseases, it is not known whether exposure to contemporary air pollutant …

Background Present treatment strategies to stratify exacerbation risk in patients with chronic
obstructive pulmonary disease (COPD) rely on a history of two or more events in the …

Background Increased concentrations of eosinophils in blood and sputum in chronic
obstructive pulmonary disease (COPD) have been associated with increased frequency of …

Background The concept that small conducting airways less than 2 mm in diameter become
the major site of airflow obstruction in chronic obstructive pulmonary disease (COPD) is well …

Rationale: The relative roles of mucus plugs and emphysema in mechanisms of airflow
limitation and hypoxemia in smokers with chronic obstructive pulmonary disease (COPD) …

Chronic obstructive pulmonary disease (COPD) is a prevalent, heterogeneous disorder with
varying presentation and progression but with a limited number of disease-modifying …

The Biomarkers Definitions Working Group defines a clinical endpoint as a variable that
reflects how a patient feels, functions, or survives (5, 6). The past 3 decades of IPF clinical …

Rationale: Black adults have worse health outcomes compared with white adults in certain
chronic diseases, including chronic obstructive pulmonary disease (COPD). Objectives: To …