Aim To synthesize international findings on the alcohol–dementia relationship, including
representation from low‐and middle‐income countries. Methods Individual participant data …

Alcohol use disorder is associated with systemic inflammation and organ dysfunction
especially in the liver and the brain. For more than a decade, studies have highlighted …

Background Brain iron deposition has been linked to several neurodegenerative conditions
and reported in alcohol dependence. Whether iron accumulation occurs in moderate …

Background Studies on the relationship between phthalate exposure and cognition in adults
are sparse and inconsistent. These studies only assessed their association of single …

Objective Early identification of cognitive impairment in neurodegenerative diseases like
Alzheimer's disease (AD) is crucial. Neurofilament, a potential biomarker for neurological …

Aldehyde dehydrogenase 2 (ALDH2) is an enzyme found in the mitochondrial matrix that
plays a central role in alcohol and aldehyde metabolism. A common ALDH2 polymorphism …

Background Research has long found 'J-shaped'relationships between alcohol consumption
and certain health outcomes, indicating a protective effect of moderate consumption …

The increased frequency of risk taking behavior combined with marked neuromaturation has
positioned adolescence as a focal point of research into the neural causes and …

Abstract Background Apolipoprotein E (APOE)-4 isoform, reelin, and clusterin share very–
low-density liporeceptor and apolipoprotein E receptor 2 receptors and are related to …

Alcohol use disorder (AUD) is a major component in the etiology of cognitive decline and
dementia. Underlying mechanisms by which long-term alcohol abuse causes cognitive …