To understand the role of cytoskeleton and membrane signaling molecules in erythroblast
enucleation, we developed a novel analysis protocol of multiparameter high-speed cell …

Erythroblasts possess unique characteristics as they undergo differentiation from
hematopoietic stem cells. During terminal erythropoiesis, these cells incorporate large …

Using RNA-seq technology, we found that the majority of microRNAs (miRNAs) present in
CFU-E erythroid progenitors are down-regulated during terminal erythroid differentiation. Of …

Mammalian erythropoiesis involves chromatin condensation that is initiated in the early
stage of terminal differentiation. The mechanisms of chromatin condensation during …

Genome-wide association studies (GWASs) have identified a genetic variant of moderate
effect size at 6p21. 1 associated with erythrocyte traits in humans. We show that this variant …

Invasive cell migration is a key step for cancer metastasis and involves Rho GTPase-
controlled reorganization of the actin cytoskeleton. Altered Rho GTPase expression is found …

We describe a case of severe neonatal anemia with kernicterus caused by compound
heterozygosity for null mutations in KLF1, each inherited from asymptomatic parents. One of …

Immunity in a naïve organism is tightly controlled. Adequate proportions of the many immune
cell subsets must be produced to mount efficient responses to eventual challenges. In …

Even though the production of orthochromatic erythroblasts can be scaled up to fulfill clinical
requirements, enucleation remains one of the critical rate‐limiting steps in the production of …

Highlights•Enucleation is a rate-limiting step in erythropoiesis that leads to the formation of
RBCs.•Regulators of enucleation range from transcription factors to miRNAs.•Optimum …