Mammalian homolog of Drosophila diaphanous (mDia) consisting of three isoforms, mDia1,
mDia2, and mDia3, is an effector of Rho GTPases that catalyzes actin nucleation and …

A unique feature in mammalian erythropoiesis is the dramatic chromatin condensation
followed by enucleation. This step-by-step process starts at the beginning of terminal …

Background Nucleus free red blood cells are unique to mammals. During their terminal
stage of differentiation, mammalian erythroblasts exit the cell cycle and enucleate. We …

Bone marrow engraftment of the hematopoietic stem and progenitor cells (HSPCs) involves
homing to the vasculatures and lodgment to their niches. How HSPCs transmigrate from the …

Mouse knockouts of Cdk2 and Cdk4 are individually viable whereas the double knockouts
are embryonic lethal due to heart defects, and this precludes the investigation of their …

Enucleation is a crucial event during the erythropoiesis, implicating drastic morphologic and
transcriptomic/proteomic changes. While many genes deletion lead to failed or impaired …

Erythropoiesis is a dynamic, multistep process whereby hematopoietic stem cells
differentiate toward a progressively committed erythroid lineage through intermediate …

Apoptotic cells are engulfed and digested by macrophages to maintain homeostasis in
animals. If dead cells are not engulfed swiftly, they undergo secondary necrosis and release …

Long noncoding RNA s (Lnc RNA s) are longer than 200 nucleotide noncoding RNA s
without apparent functional coding capacity that function as regulators of cell growth and …

Formins, proteins defined by the presence of an FH2 domain and their ability to nucleate
linear F-actin de novo, play a key role in the regulation of the cytoskeleton. Initially thought to …