Nutritional immunity: the battle for nutrient metals at the host–pathogen interface

CC Murdoch, EP Skaar - Nature Reviews Microbiology, 2022 - nature.com
Trace metals are essential micronutrients required for survival across all kingdoms of life.
From bacteria to animals, metals have critical roles as both structural and catalytic cofactors …

Oxidative stress response: a critical factor affecting the ecological competitiveness of Streptococcus mutans

X Cheng, X Xu, X Zhou, J Ning - Journal of Oral Microbiology, 2024 - Taylor & Francis
Oral microecological balance is closely associated with the development of dental caries.
Oxidative stress is one of the important factors regulating the composition and structure of …

Gliotoxin-mediated bacterial growth inhibition is caused by specific metal ion depletion

SG Downes, RA Owens, K Walshe, DA Fitzpatrick… - Scientific Reports, 2023 - nature.com
Overcoming antimicrobial resistance represents a formidable challenge and investigating
bacterial growth inhibition by fungal metabolites may yield new strategies. Although the …

ZccE is a Novel P-type ATPase That Protects Streptococcus mutans Against Zinc Intoxication

T Ganguly, AM Peterson, M Burkholder… - Plos …, 2022 - journals.plos.org
Zinc is a trace metal that is essential to all forms of life, but that becomes toxic at high
concentrations. Because it has both antimicrobial and anti-inflammatory properties and low …

The Adc regulon mediates zinc homeostasis in Streptococcus mutans

Y Pan, Y Chen, J Chen, Q Ma, T Gong… - Molecular Oral …, 2021 - Wiley Online Library
Abstract Zinc (Zn2+) is an essential divalent trace metal for living cells. Intracellular zinc
homeostasis is critical to the survival and virulence of bacteria. Thus, the frequent …

Contribution of a ZIP‐family protein to manganese uptake and infective endocarditis virulence in Streptococcus sanguinis

T Puccio, KS Kunka, SS An, T Kitten - Molecular microbiology, 2022 - Wiley Online Library
Streptococcus sanguinis is an important cause of infective endocarditis. In strain SK36, the
ABC‐family manganese transporter, SsaACB, is essential for virulence. We have now …

The AdcACB/AdcAII system is essential for zinc homeostasis and an important contributor of Enterococcus faecalis virulence

LN Lam, DN Brunson, JJ Molina, AL Flores-Mireles… - Virulence, 2022 - Taylor & Francis
Bacterial pathogens require a variety of micronutrients for growth, including trace metals
such as iron, manganese, and zinc (Zn). Despite their relative abundance in host …

ZccE, a P‐type ATPase contributing to biofilm formation and competitiveness in Streptococcus mutans

Y Pan, J Zou, K Zhang, X Wang, Q Ma… - Molecular Oral …, 2023 - Wiley Online Library
Most living organisms require zinc for survival; however, excessive amounts of this trace
element can be toxic. Therefore, the frequent fluctuations of salivary zinc, caused by the low …

Effect of the zinc transporter ZupT on the virulence mechanisms of mesophilic Aeromonas salmonicida SRW‐OG1

J Wang, Q Li, L Huang - Animal Research and One Health, 2023 - Wiley Online Library
As a typical psychrophilic bacterial pathogen, Aeromonas salmonicida causes furunculosis
in wild and farmed freshwater and marine fish, leading to substantial economic losses in the …

ZrgA contributes to zinc acquisition in Vibrio parahaemolyticus

C Zheng, J Qiu, Y Zhai, M Wei, X Zhou, X Jiao - Virulence, 2023 - Taylor & Francis
Metals are nutrients essential for almost all lifeforms. Bacteria have evolved several
mechanisms to overcome the metal restrictions imposed by the host. Vibrio …