[HTML][HTML] Targeting human proteins for antiviral drug discovery and repurposing efforts: a focus on protein kinases

R Hajjo, DA Sabbah, OH Abusara, R Kharmah… - Viruses, 2023 - mdpi.com
Despite the great technological and medical advances in fighting viral diseases, new
therapies for most of them are still lacking, and existing antivirals suffer from major limitations …

Design, synthesis and anti-cancer evaluation of genistein-1, 3, 5-triazine derivatives

JP Zou, Z Zhang, JY Lv, XQ Zhang, ZY Zhang, ST Han… - Tetrahedron, 2023 - Elsevier
Abstract Twelve genistein-1, 3, 5-triazine derivatives were synthesized by nucleophilic
substitution and characterized by 1 H NMR, 13 C NMR, IR, HR-MS and single crystal X-ray …

[HTML][HTML] Selective inhibitors targeting Fis1/Mid51 protein-protein interactions protect against hypoxia-induced damage in cardiomyocytes

M Zerihun, N Qvit - Frontiers in Pharmacology, 2023 - frontiersin.org
Cardiovascular diseases (CVDs) are the most common non-communicable diseases
globally. An estimated 17.9 million people died from CVDs in 2019, representing 32% of all …

[HTML][HTML] The influence of COVID-19 on colorectal cancer was investigated using bioinformatics and systems biology techniques

Y Song, T Huang, H Pan, A Du, T Wu, J Lan… - Frontiers in …, 2023 - frontiersin.org
Introduction Coronavirus disease 2019 (COVID-19) is a global pandemic and highly
contagious, posing a serious threat to human health. Colorectal cancer (CRC) is a risk factor …

[HTML][HTML] Identifying hub genes and common biological pathways between COVID-19 and benign prostatic hyperplasia by machine learning algorithms

H Zhou, M Xu, P Hu, Y Li, C Ren, M Li, Y Pan… - Frontiers in …, 2023 - frontiersin.org
Background COVID-19, a serious respiratory disease that has the potential to affect
numerous organs, is a serious threat to the health of people around the world. The objective …

Exploring the Potential Mechanisms of Guanxinshutong Capsules in Treating Pathological Cardiac Hypertrophy based on Network Pharmacology, Computer-Aided …

Y Liu, Q Li, C Shao, Y She, H Zhou, Y Guo, H An… - ACS …, 2024 - ACS Publications
Cardiovascular diseases (CVDs) are significant causes of morbidity and mortality worldwide,
and pathological cardiac hypertrophy (PCH) is an essential predictor of many heart …

Ultrasensitive electrochemical immunosensor based on Fe3O4@gC3N4 nanocomposites for detection of TCM root-rot early warning biomarker - zearalenone

B Sun, Q Dang, C Gao, H Shi, Q Ma, Y Liu, S Yu… - Journal of Solid State …, 2024 - Springer
Root rot is a highly infectious disease in traditional Chinese medicine (TCM) that spreads
quickly and significantly affects the yield and quality of TCM. Therefore, there is an urgent …

Inhibitory potential of phytochemicals on five SARS-CoV-2 proteins: in silico evaluation of endemic plants of Bosnia and Herzegovina

T Corbo, A Kalajdzic, D Omerkic, F Catic… - Biotechnology & …, 2023 - Taylor & Francis
The outbreak of the coronavirus disease 2019, caused by the SARS-CoV-2 virus, has
prompted global health concerns. In response, researchers have been conducting …