Biological subtyping of psychiatric syndromes as a pathway for advances in drug discovery and personalized medicine

W Zhang, JA Sweeney, JR Bishop, Q Gong… - Nature Mental …, 2023 - nature.com
Every common psychiatric syndrome is genetically, neurobiologically and clinically
heterogeneous. This heterogeneity may reflect the dimensional variability of a single illness …

Evidence for reduced sensory precision and increased reliance on priors in hallucination-prone individuals in a general population sample

D Benrimoh, VL Fisher, R Seabury… - Schizophrenia …, 2024 - academic.oup.com
Background There is increasing evidence that people with hallucinations overweight
perceptual beliefs relative to incoming sensory evidence. Past work demonstrating prior …

A computational lens on menopause-associated psychosis

VL Fisher, LS Ortiz, AR Powers III - Frontiers in Psychiatry, 2022 - frontiersin.org
Psychotic episodes are debilitating disease states that can cause extreme distress and
impair functioning. There are sex differences that drive the onset of these episodes. One …

A novel computational approach to pain perception modelling within a Bayesian framework using quantitative sensory testing

A Drusko, D Baumeister, M McPhee Christensen… - Scientific Reports, 2023 - nature.com
Pain perception can be studied as an inferential process in which prior information
influences the perception of nociceptive input. To date, there are no suitable psychophysical …

Recent social stress and severity of auditory hallucinations

EA Farina, C Mourgues-Codern, E Sibarium… - Schizophrenia …, 2024 - Elsevier
Background and hypothesis Hearing voices is a common and often distressing experience
for people with psychosis, and many individuals experience medication-resistant auditory …

Mathematical nosology: computational approaches to understanding psychosis

AR Powers - Schizophrenia Research, 2022 - Elsevier
Few words in modern psychiatric research evoke as much enthusiasm, frustration, and
general confusion as the term computational. Despite significant investment from the …

Perceptual expectations and false percepts generate stimulus-specific activity in distinct layers of the early visual cortex

J Haarsma, N Deveci, N Corbin, MF Callaghan, P Kok - bioRxiv, 2022 - biorxiv.org
Perception has been proposed to result from the integration of feedforward sensory signals
with internally generated feedback signals. The latter are believed to play an important role …

Computational psychiatry and the psychopathology of psychosis: Promising leads and blind alleys.

R Tandon - 2023 - psycnet.apa.org
The letter discusses about the computational psychiatry and the psychopathology of
psychosis. Despite rich descriptions and extensive study, the neurobiological substrate of …

[HTML][HTML] A computational account of the development and evolution of psychotic symptoms

A Powers, P Angelos, A Bond, E Farina, C Fredericks… - ArXiv, 2024 - ncbi.nlm.nih.gov
The mechanisms of psychotic symptoms like hallucinations and delusions are often
investigated in fully-formed illness, well after symptoms emerge. These investigations have …

Modeling pain perception within a Bayesian framework–a novel computational approach to quantify predictive pain processing using quantitative sensory testing

A Drusko, D Baumeister, MEMP Christensen… - 2022 - researchsquare.com
Pain perception can be studied as an inferential process in which prior information
influences the perception of nociceptive input. To date, there are no suitable psychophysical …