Biological subtyping of psychiatric syndromes as a pathway for advances in drug discovery and personalized medicine
Every common psychiatric syndrome is genetically, neurobiologically and clinically
heterogeneous. This heterogeneity may reflect the dimensional variability of a single illness …
heterogeneous. This heterogeneity may reflect the dimensional variability of a single illness …
Evidence for reduced sensory precision and increased reliance on priors in hallucination-prone individuals in a general population sample
Background There is increasing evidence that people with hallucinations overweight
perceptual beliefs relative to incoming sensory evidence. Past work demonstrating prior …
perceptual beliefs relative to incoming sensory evidence. Past work demonstrating prior …
A computational lens on menopause-associated psychosis
VL Fisher, LS Ortiz, AR Powers III - Frontiers in Psychiatry, 2022 - frontiersin.org
Psychotic episodes are debilitating disease states that can cause extreme distress and
impair functioning. There are sex differences that drive the onset of these episodes. One …
impair functioning. There are sex differences that drive the onset of these episodes. One …
A novel computational approach to pain perception modelling within a Bayesian framework using quantitative sensory testing
A Drusko, D Baumeister, M McPhee Christensen… - Scientific Reports, 2023 - nature.com
Pain perception can be studied as an inferential process in which prior information
influences the perception of nociceptive input. To date, there are no suitable psychophysical …
influences the perception of nociceptive input. To date, there are no suitable psychophysical …
Recent social stress and severity of auditory hallucinations
EA Farina, C Mourgues-Codern, E Sibarium… - Schizophrenia …, 2024 - Elsevier
Background and hypothesis Hearing voices is a common and often distressing experience
for people with psychosis, and many individuals experience medication-resistant auditory …
for people with psychosis, and many individuals experience medication-resistant auditory …
Mathematical nosology: computational approaches to understanding psychosis
AR Powers - Schizophrenia Research, 2022 - Elsevier
Few words in modern psychiatric research evoke as much enthusiasm, frustration, and
general confusion as the term computational. Despite significant investment from the …
general confusion as the term computational. Despite significant investment from the …
Perceptual expectations and false percepts generate stimulus-specific activity in distinct layers of the early visual cortex
Perception has been proposed to result from the integration of feedforward sensory signals
with internally generated feedback signals. The latter are believed to play an important role …
with internally generated feedback signals. The latter are believed to play an important role …
Computational psychiatry and the psychopathology of psychosis: Promising leads and blind alleys.
R Tandon - 2023 - psycnet.apa.org
The letter discusses about the computational psychiatry and the psychopathology of
psychosis. Despite rich descriptions and extensive study, the neurobiological substrate of …
psychosis. Despite rich descriptions and extensive study, the neurobiological substrate of …
[HTML][HTML] A computational account of the development and evolution of psychotic symptoms
The mechanisms of psychotic symptoms like hallucinations and delusions are often
investigated in fully-formed illness, well after symptoms emerge. These investigations have …
investigated in fully-formed illness, well after symptoms emerge. These investigations have …
Modeling pain perception within a Bayesian framework–a novel computational approach to quantify predictive pain processing using quantitative sensory testing
A Drusko, D Baumeister, MEMP Christensen… - 2022 - researchsquare.com
Pain perception can be studied as an inferential process in which prior information
influences the perception of nociceptive input. To date, there are no suitable psychophysical …
influences the perception of nociceptive input. To date, there are no suitable psychophysical …