Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS), affect millions of people …

Skeletal muscle possesses remarkable plasticity that permits functional adaptations to a
wide range of signals such as motor input, exercise, and disease. Small animal models have …

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease in
adults with no curative treatment. Neurofilament (NF) level in patient'fluids have recently …

Induced pluripotent stem cells and their derivatives have become an important tool for
researching disease mechanisms. It is hoped that they could be used to discover new …

A multitude of in vitro models based on induced pluripotent stem cell (iPSC)-derived motor
neurons (MNs) have been developed to investigate the underlying causes of selective MN …

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease that leads to
widespread motor neuron death, general palsy and respiratory failure. The most prevalent …

During the process of neurogenesis, the stem cell committed to the neuronal cell fate starts a
series of molecular and morphological changes. The understanding of the physio-pathology …

Skeletal muscle, which comprises a significant portion of the body, is responsible for vital
functions such as movement, metabolism, and overall health. However, severe injuries often …

Generation of autologous human motor neurons holds great promise for cell replacement
therapy to treat spinal cord injury (SCI). Direct conversion allows generation of target cells …

The study of neurological disorders often presents with significant challenges due to the
inaccessibility of human neuronal cells for further investigation. Advances in cellular …