[HTML][HTML] 2D versus 3D human induced pluripotent stem cell-derived cultures for neurodegenerative disease modelling
Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS), affect millions of people …
Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS), affect millions of people …
[HTML][HTML] Tissue-engineered skeletal muscle models to study muscle function, plasticity, and disease
A Khodabukus - Frontiers in Physiology, 2021 - frontiersin.org
Skeletal muscle possesses remarkable plasticity that permits functional adaptations to a
wide range of signals such as motor input, exercise, and disease. Small animal models have …
wide range of signals such as motor input, exercise, and disease. Small animal models have …
[HTML][HTML] Neurofilament accumulations in amyotrophic lateral sclerosis patients' motor neurons impair axonal initial segment integrity
C Lefebvre-Omar, E Liu, C Dalle, BL d'Incamps… - Cellular and Molecular …, 2023 - Springer
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease in
adults with no curative treatment. Neurofilament (NF) level in patient'fluids have recently …
adults with no curative treatment. Neurofilament (NF) level in patient'fluids have recently …
Using stem cell–derived neurons in drug screening for neurological diseases
Induced pluripotent stem cells and their derivatives have become an important tool for
researching disease mechanisms. It is hoped that they could be used to discover new …
researching disease mechanisms. It is hoped that they could be used to discover new …
[HTML][HTML] An optimized workflow to generate and characterize iPSC-derived motor neuron (MN) spheroids
MJ Castellanos-Montiel, M Chaineau… - Cells, 2023 - mdpi.com
A multitude of in vitro models based on induced pluripotent stem cell (iPSC)-derived motor
neurons (MNs) have been developed to investigate the underlying causes of selective MN …
neurons (MNs) have been developed to investigate the underlying causes of selective MN …
[HTML][HTML] Gene expression profiling for human iPS-derived motor neurons from sporadic ALS patients reveals a strong association between mitochondrial functions and …
CJ Alves, R Dariolli, FM Jorge, MR Monteiro… - Frontiers in cellular …, 2015 - frontiersin.org
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease that leads to
widespread motor neuron death, general palsy and respiratory failure. The most prevalent …
widespread motor neuron death, general palsy and respiratory failure. The most prevalent …
[HTML][HTML] The cytoskeletal arrangements necessary to neurogenesis
C Compagnucci, F Piemonte, A Sferra, E Piermarini… - Oncotarget, 2016 - ncbi.nlm.nih.gov
During the process of neurogenesis, the stem cell committed to the neuronal cell fate starts a
series of molecular and morphological changes. The understanding of the physio-pathology …
series of molecular and morphological changes. The understanding of the physio-pathology …
[HTML][HTML] Induced Pluripotent Stem Cells for Tissue-Engineered Skeletal Muscles
Skeletal muscle, which comprises a significant portion of the body, is responsible for vital
functions such as movement, metabolism, and overall health. However, severe injuries often …
functions such as movement, metabolism, and overall health. However, severe injuries often …
[HTML][HTML] Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model
H Lee, HY Lee, BE Lee, D Gerovska, SY Park… - Elife, 2020 - elifesciences.org
Generation of autologous human motor neurons holds great promise for cell replacement
therapy to treat spinal cord injury (SCI). Direct conversion allows generation of target cells …
therapy to treat spinal cord injury (SCI). Direct conversion allows generation of target cells …
[HTML][HTML] Utility of induced pluripotent stem cells for the study and treatment of genetic diseases: focus on childhood neurological disorders
S Barral, MA Kurian - Frontiers in molecular neuroscience, 2016 - frontiersin.org
The study of neurological disorders often presents with significant challenges due to the
inaccessibility of human neuronal cells for further investigation. Advances in cellular …
inaccessibility of human neuronal cells for further investigation. Advances in cellular …