Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis

L Wang, C He - Frontiers in immunology, 2022 - frontiersin.org
Macrophages are the most abundant immune cells within the synovial joints, and also the
main innate immune effector cells triggering the initial inflammatory responses in the …

Inflammatory mediators of cytokines and chemokines in sepsis: From bench to bedside

Z Doganyigit, E Eroglu, E Akyuz - Human & experimental …, 2022 - journals.sagepub.com
Background: Sepsis is a serious clinical condition characterized by damage to the immune
system as a result of an uncontrolled response to infection. Septic patients show …

Targeting NRF2–KEAP1 axis by Omega-3 fatty acids and their derivatives: Emerging opportunities against aging and diseases

S Davinelli, A Medoro, M Intrieri, L Saso… - Free Radical Biology …, 2022 - Elsevier
The transcription factor NRF2 and its endogenous inhibitor KEAP1 play a crucial role in the
maintenance of cellular redox homeostasis by regulating the gene expression of diverse …

Research progress on the mechanism of sepsis induced myocardial injury

CF Bi, J Liu, LS Yang, JF Zhang - Journal of inflammation research, 2022 - Taylor & Francis
Sepsis is an abnormal condition with multiple organ dysfunctions caused by the
uncontrolled infection response and one of the major diseases that seriously hang over …

Maresin-1 and inflammatory disease

N Saito-Sasaki, Y Sawada, M Nakamura - International journal of …, 2022 - mdpi.com
Inflammation is an essential action to protect the host human body from external, harmful
antigens and microorganisms. However, an excessive inflammation reaction sometimes …

Omega-3 lipid mediators: modulation of the M1/M2 macrophage phenotype and its protective role in chronic liver diseases

LA Videla, R Valenzuela, A Del Campo… - International Journal of …, 2023 - mdpi.com
The complex interplay between dietary factors, inflammation, and macrophage polarization
is pivotal in the pathogenesis and progression of chronic liver diseases (CLDs). Omega-3 …

[HTML][HTML] Resolvin D2 and its receptor GPR18 in cardiovascular and metabolic diseases: A promising biomarker and therapeutic target

M Zhao, Z Zheng, Z Yin, J Zhang, J Qin, J Wan… - Pharmacological …, 2023 - Elsevier
Accumulating evidence suggests that inflammation plays an important role in the
pathophysiology of the initiation and progression of cardiovascular and metabolic diseases …

Maresin1 suppresses high-glucose-induced ferroptosis in osteoblasts via NRF2 activation in type 2 diabetic osteoporosis

Z Zhang, C Ji, YN Wang, S Liu, M Wang, X Xu, D Zhang - Cells, 2022 - mdpi.com
Maresin1 (MaR1) is an endogenous pro-resolving lipid mediator produced from
polyunsaturated fatty acids and is believed to have antioxidant and anti-inflammatory …

MCTR1 inhibits ferroptosis by promoting NRF2 expression to attenuate hepatic ischemia-reperfusion injury

J Ye, J Peng, K Liu, T Zhang… - American Journal of …, 2022 - journals.physiology.org
Hepatic ischemia-reperfusion injury (HIRI) can lead to poor prognosis in patients
undergoing liver transplantation or extensive liver resection. Maresin conjugate in tissue …

Specialized pro-resolving mediators as modulators of immune responses

WA Julliard, YPA Myo, A Perelas, PD Jackson… - Seminars in …, 2022 - Elsevier
Specialized pro-resolving mediators (SPMs) are endogenous small molecules produced
mainly from dietary omega-3 polyunsaturated fatty acids by both structural cells and cells of …