Triboelectric nanogenerators for therapeutic electrical stimulation

G Conta, A Libanori, T Tat, G Chen… - Advanced Materials, 2021 - Wiley Online Library
Current solutions developed for the purpose of in and on body (IOB) electrical stimulation
(ES) lack autonomous qualities necessary for comfortable, practical, and self‐dependent …

Implantable triboelectric nanogenerators for self‐powered cardiovascular healthcare

Z Che, S O'Donovan, X Xiao, X Wan, G Chen, X Zhao… - Small, 2023 - Wiley Online Library
Triboelectric nanogenerators (TENGs) have gained significant traction in recent years in the
bioengineering community. With the potential for expansive applications for biomedical use …

Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs

Y Li, X Chen, R Jin, L Chen, M Dang, H Cao… - Science …, 2021 - science.org
Current therapeutic strategies such as angiogenic therapy and anti-inflammatory therapy for
treating myocardial infarction have limited success. An effective approach may benefit from …

Cardiac regeneration strategies: staying young at heart

E Tzahor, KD Poss - Science, 2017 - science.org
The human heart is continually operating as a muscular pump, contracting, on average, 80
times per minute to propel 8000 liters of blood through body tissues each day. Whereas …

Little fish, big data: zebrafish as a model for cardiovascular and metabolic disease

P Gut, S Reischauer, DYR Stainier… - Physiological …, 2017 - journals.physiology.org
The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

[HTML][HTML] Myocardial polyploidization creates a barrier to heart regeneration in zebrafish

JM González-Rosa, M Sharpe, D Field, MH Soonpaa… - Developmental cell, 2018 - cell.com
Correlative evidence suggests that polyploidization of heart muscle, which occurs naturally
in post-natal mammals, creates a barrier to heart regeneration. Here, we move beyond a …

The epicardium as a hub for heart regeneration

J Cao, KD Poss - Nature Reviews Cardiology, 2018 - nature.com
After decades of directed research, no effective regenerative therapy is currently available to
repair the injured human heart. The epicardium, a layer of mesothelial tissue that envelops …

ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration

A Aharonov, A Shakked, KB Umansky, A Savidor… - Nature cell …, 2020 - nature.com
Cardiomyocyte loss after injury results in adverse remodelling and fibrosis, inevitably
leading to heart failure. The ERBB2–Neuregulin and Hippo–YAP signalling pathways are …

Heart regeneration by endogenous stem cells and cardiomyocyte proliferation: controversy, fallacy, and progress

L He, NB Nguyen, R Ardehali, B Zhou - Circulation, 2020 - Am Heart Assoc
Ischemic heart disease is the leading cause of death worldwide. Myocardial infarction
results in an irreversible loss of cardiomyocytes with subsequent adverse remodeling and …

Multicellular transcriptional analysis of mammalian heart regeneration

GA Quaife-Ryan, CB Sim, M Ziemann, A Kaspi… - Circulation, 2017 - Am Heart Assoc
Background: The inability of the adult mammalian heart to regenerate following injury
represents a major barrier in cardiovascular medicine. In contrast, the neonatal mammalian …