Triboelectric nanogenerators for therapeutic electrical stimulation
Current solutions developed for the purpose of in and on body (IOB) electrical stimulation
(ES) lack autonomous qualities necessary for comfortable, practical, and self‐dependent …
(ES) lack autonomous qualities necessary for comfortable, practical, and self‐dependent …
Implantable triboelectric nanogenerators for self‐powered cardiovascular healthcare
Triboelectric nanogenerators (TENGs) have gained significant traction in recent years in the
bioengineering community. With the potential for expansive applications for biomedical use …
bioengineering community. With the potential for expansive applications for biomedical use …
Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs
Y Li, X Chen, R Jin, L Chen, M Dang, H Cao… - Science …, 2021 - science.org
Current therapeutic strategies such as angiogenic therapy and anti-inflammatory therapy for
treating myocardial infarction have limited success. An effective approach may benefit from …
treating myocardial infarction have limited success. An effective approach may benefit from …
Cardiac regeneration strategies: staying young at heart
The human heart is continually operating as a muscular pump, contracting, on average, 80
times per minute to propel 8000 liters of blood through body tissues each day. Whereas …
times per minute to propel 8000 liters of blood through body tissues each day. Whereas …
Little fish, big data: zebrafish as a model for cardiovascular and metabolic disease
The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …
emergence of systems approaches in biology promises new therapies, faster and cheaper …
[HTML][HTML] Myocardial polyploidization creates a barrier to heart regeneration in zebrafish
JM González-Rosa, M Sharpe, D Field, MH Soonpaa… - Developmental cell, 2018 - cell.com
Correlative evidence suggests that polyploidization of heart muscle, which occurs naturally
in post-natal mammals, creates a barrier to heart regeneration. Here, we move beyond a …
in post-natal mammals, creates a barrier to heart regeneration. Here, we move beyond a …
The epicardium as a hub for heart regeneration
After decades of directed research, no effective regenerative therapy is currently available to
repair the injured human heart. The epicardium, a layer of mesothelial tissue that envelops …
repair the injured human heart. The epicardium, a layer of mesothelial tissue that envelops …
ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration
A Aharonov, A Shakked, KB Umansky, A Savidor… - Nature cell …, 2020 - nature.com
Cardiomyocyte loss after injury results in adverse remodelling and fibrosis, inevitably
leading to heart failure. The ERBB2–Neuregulin and Hippo–YAP signalling pathways are …
leading to heart failure. The ERBB2–Neuregulin and Hippo–YAP signalling pathways are …
Heart regeneration by endogenous stem cells and cardiomyocyte proliferation: controversy, fallacy, and progress
Ischemic heart disease is the leading cause of death worldwide. Myocardial infarction
results in an irreversible loss of cardiomyocytes with subsequent adverse remodeling and …
results in an irreversible loss of cardiomyocytes with subsequent adverse remodeling and …
Multicellular transcriptional analysis of mammalian heart regeneration
Background: The inability of the adult mammalian heart to regenerate following injury
represents a major barrier in cardiovascular medicine. In contrast, the neonatal mammalian …
represents a major barrier in cardiovascular medicine. In contrast, the neonatal mammalian …