Folate is an essential micronutrient required for both cellular proliferation through de novo
nucleotide synthesis and epigenetic regulation of gene expression through methylation. This …

The precise wiring of the nervous system is a combined outcome of progressive and
regressive events during development. Axon guidance and synapse formation intertwined …

Correct mitochondrial distribution is critical for satisfying local energy demands and calcium
buffering requirements and supporting key cellular processes. The mitochondrially targeted …

Infrared fluorescent proteins (IFPs) are ideal for in vivo imaging, and monomeric versions of
these proteins can be advantageous as protein tags or for sensor development. In contrast …

How neurons develop their morphology is an important question in neurobiology. Here we
describe a new pathway that specifically affects the formation of basal dendrites and axonal …

Children who survive preterm birth exhibit persistent unexplained disturbances in cerebral
cortical growth with associated cognitive and learning disabilities. The mechanisms …

Summary The 22 γ-protocadherins (γ-Pcdhs) potentially specify thousands of distinct
homophilic adhesive interactions in the brain. Neonatal lethality of mice lacking the Pcdh-γ …

During nervous system development, axons generate branches to connect with multiple
synaptic targets. As with axon growth and guidance, axon branching is tightly controlled in …

Dendrites of the same neuron usually avoid each other. Some neurons also repel similar
neurons through dendrite-dendrite interaction to tile the receptive field. Nonoverlapping …

Neurons are highly polarized cells with a single axon and multiple dendrites derived from
the cell body to form tightly associated pre-and postsynaptic compartments. As the …