TMEM 106B is a major risk factor for frontotemporal lobar degeneration with TDP‐43
pathology. TMEM 106B localizes to lysosomes, but its function remains unclear. We show …

Neurons are highly polarized cells with a single axon and multiple dendrites derived from
the cell body to form tightly associated pre-and postsynaptic compartments. As the …

Sensory dendrites depend on cues from their environment to pattern their growth and direct
them toward their correct target tissues. Yet, little is known about dendrite-substrate …

Thermosensation is critical for avoiding thermal extremes and regulating body temperature.
While thermosensors activated by noxious temperatures respond to hot or cold, many …

Neuronal arborization is regulated by cell-autonomous and nonautonomous mechanisms
including endosomal signaling via BDNF/TrkB. The endosomal Na+/H+ exchanger 6 …

Macrocephaly affects up to 5% of the pediatric population and is defined as an abnormally
large head with an occipitofrontal circumference (OFC)> 2 standard deviations (SD) above …

Maternal immune activation increases the risk of neurodevelopmental disorders. Elevated
cytokines, such as interferon-γ (IFN-γ), in offspring's brains play a central role. IFN-γ …

It has been proposed that two amino acid substitutions in the transcription factor FOXP2
have been positively selected during human evolution and influence aspects of speech and …

Dendrites are the main site of information input into neurons. Their development is a
multistep process controlled by mammalian target of rapamycin (mTOR) among other …

The complex, branched morphology of dendrites is a cardinal feature of neurons and has
been used as a criterion for cell type identification since the beginning of neurobiology …