Interest in CD8+ T cells and B cells was initially inspired by observations in multiple
sclerosis rather than in animal models: CD8+ T cells predominate in multiple sclerosis …

A better understanding of immune-mediated mechanisms in the pathogenesis of multiple
sclerosis and the contribution of environmental risk factors toward the development of …

In addition to CD4+ regulatory T cells (Tregs), CD8+ suppressor T cells are emerging as an
important subset of regulatory T cells. Diverse populations of CD8+ T cells with suppressive …

Autoimmune diseases are usually complex and multifactorial, characterized by aberrant
production of autoreactive immune cells and/or autoantibodies against healthy cells and …

Multiple sclerosis (MS) is the prototypic inflammatory disease of the central nervous system
(CNS) characterized by multifocal areas of demyelination, axonal damage, activation of glial …

Various subgroups of CD8+ T lymphocytes do not only demonstrate cytotoxic effects, but
also serve important regulatory roles in the body's immune response. In particular, CD8+ …

Vitamin D is a secosteroid hormone that is highly involved in bone health. Mounting
evidence revealed that, in addition to the regulation of mineral metabolism, vitamin D is …

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
characterized by focal demyelination patches associated with inflammatory infiltrates …

The cardinal dogma of central nervous system (CNS) immunology believed brain is an
immune privileged site, but scientific evidences gathered so far have overturned this notion …

The vast majority of studies regarding the immune basis of MS (and its animal model, EAE)
have largely focused on CD4+ T-cells as mediators and regulators of disease. Interestingly …