Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions

X Dong-Chen, C Yong, X Yang, ST Chen-Yu… - Signal transduction and …, 2023 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …

Puerarin: a review of pharmacological effects

YX Zhou, H Zhang, C Peng - Phytotherapy Research, 2014 - Wiley Online Library
Puerarin is the major bioactive ingredient isolated from the root of the Pueraria lobata
(Willd.) Ohwi, which is well known as Gegen (Chinese name) in traditional Chinese …

Oxidative stress and Parkinson's disease: new hopes in treatment with herbal antioxidants

A Sarrafchi, M Bahmani, H Shirzad… - Current …, 2016 - ingentaconnect.com
Parkinson's disease (PD) is a neurodegenerative disorder due to dopamine deficit in
substatia nigra. PD is mainly a sporadic disease with unestablished etiology. However …

Gastrodin protects against glutamate-induced ferroptosis in HT-22 cells through Nrf2/HO-1 signaling pathway

T Jiang, H Cheng, J Su, X Wang, Q Wang, J Chu, Q Li - Toxicology in Vitro, 2020 - Elsevier
Gastrodin (GAS) is a component of Gastrodia elata Blume, with strong antioxidant activity in
neurodegenerative diseases. Ferroptosis is similar to glutamate-induced cell death. This …

[HTML][HTML] The PI3K-AKT pathway: A plausible therapeutic target in Parkinson's disease

A Goyal, A Agrawal, A Verma, N Dubey - Experimental and Molecular …, 2023 - Elsevier
Parkinson's disease is a common progressive and multifactorial neurodegenerative disease,
characterized by the loss of midbrain dopaminergic neurons. Numerous pathological …

The entrancing role of dietary polyphenols against the most frequent aging‐associated diseases

MA Shah, HI Faheem, A Hamid… - Medicinal Research …, 2024 - Wiley Online Library
Aging, a fundamental physiological process influenced by innumerable biological and
genetic pathways, is an important driving factor for several aging‐associated disorders like …

Nanoparticles mediating the sustained puerarin release facilitate improved brain delivery to treat Parkinson's disease

T Chen, W Liu, S Xiong, D Li, S Fang… - … applied materials & …, 2019 - ACS Publications
Recent work has highlighted the potential of puerarin (PU) as a valuable compound to treat
Parkinson's disease (PD), but its undesirable water solubility and bioavailability have …

Progress on the pharmacological research of puerarin: a review

WEI Shu-Yong, C Yi, XU Xiao-Yu - Chinese Journal of Natural Medicines, 2014 - Elsevier
Contemporary pharmacological research has demonstrated that puerarin, the most
important phytoestrogen extracted from Pueraria lobata (Willd.) Ohwi, has protecting …

[HTML][HTML] Neuroprotective mechanisms of puerarin in central nervous system diseases: Update

CC Yu, YJ Du, J Li, Y Li, L Wang, LH Kong… - Aging and …, 2022 - ncbi.nlm.nih.gov
Due to global population aging and modern lifestyle changes, the incidence of central
nervous system (CNS) disorders, such as neurodegenerative diseases, neuropsychiatric …

Plants‐derived neuroprotective agents: cutting the cycle of cell death through multiple mechanisms

TO Elufioye, TI Berida… - … and Alternative Medicine, 2017 - Wiley Online Library
Neuroprotection is the preservation of the structure and function of neurons from insults
arising from cellular injuries induced by a variety of agents or neurodegenerative diseases …