Impressive advances in defining the properties of receptors for the Fc portion of
immunoglobulins (FcR) have been made over the past several years. Ligand specificities …

The direct or indirect targeting of antibody Fc receptors (FcRs) presents unique opportunities
and interesting challenges for the treatment of inflammatory diseases, cancer and infection …

CD47 acts as a" don't eat me" signal that protects cells from phagocytosis by binding and
activating its receptor SIPRA on macrophages. CD47 suppresses multiple different pro …

Macrophages protect the body from damage and disease by targeting antibody-opsonized
cells for phagocytosis. Though antibodies can be raised against antigens with diverse …

IgG4, the least represented human IgG subclass in serum, is an intriguing antibody with
unique biological properties, such as the ability to undergo Fab‐arm exchange and limit …

Cell-surface Fcγ receptors mediate innate and adaptive immune responses. Human Fcγ
receptor I (hFcγRI) binds IgGs with high affinity and is the only Fcγ receptor that can …

Fc gamma receptor I (FcγRI) contributes to protective immunity against bacterial infections,
but exacerbates certain autoimmune diseases. The sole high-affinity IgG receptor, FcγRI …

To date, no curative therapy is available for the treatment of most chronic inflammatory
diseases such as atopic dermatitis, rheumatoid arthritis, or autoimmune disorders. Current …

Immunoglobulin E (IgE) is well known for its role in allergic disease, the manifestations of
which are mediated through its two Fc receptors, Fcε RI and CD 23 (Fcε RII). IgE and its …

Immunoglobulins and Fc receptors are critical glycoprotein components of the immune
system. Fc receptors bind the Fc (effector) region of antibody molecules and communicate …