Microfluidics for neuronal cell and circuit engineering

R Habibey, JE Rojo Arias, J Striebel… - Chemical …, 2022 - ACS Publications
The widespread adoption of microfluidic devices among the neuroscience and neurobiology
communities has enabled addressing a broad range of questions at the molecular, cellular …

Generating and using transcriptomically based retinal cell atlases

K Shekhar, JR Sanes - Annual Review of Vision Science, 2021 - annualreviews.org
It has been known for over a century that the basic organization of the retina is conserved
across vertebrates. It has been equally clear that retinal cells can be classified into …

Functional neuronal circuitry and oscillatory dynamics in human brain organoids

T Sharf, T Van Der Molen, SMK Glasauer… - Nature …, 2022 - nature.com
Human brain organoids replicate much of the cellular diversity and developmental anatomy
of the human brain. However, the physiology of neuronal circuits within organoids remains …

Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology

R Xu, AJ Boreland, X Li, C Erickson, M Jin, C Atkins… - Stem cell reports, 2021 - cell.com
Microglia play critical roles in brain development, homeostasis, and disease. Microglia in
animal models cannot accurately model human microglia due to notable transcriptomic and …

[HTML][HTML] Extension of retinofugal projections in an assembled model of human pluripotent stem cell-derived organoids

CM Fligor, SS Lavekar, J Harkin, PK Shields… - Stem Cell Reports, 2021 - cell.com
The development of the visual system involves the coordination of spatial and temporal
events to specify the organization of varied cell types, including the elongation of axons from …

Microplastics exposure affects neural development of human pluripotent stem cell-derived cortical spheroids

T Hua, S Kiran, Y Li, QXA Sang - Journal of Hazardous Materials, 2022 - Elsevier
Plastics have been part of our ecosystem for about a century and their degradation by
different environmental factors produce secondary microplastics (MPs). To date, the impact …

[HTML][HTML] Gene regulatory network analysis and engineering directs development and vascularization of multilineage human liver organoids

JJ Velazquez, R LeGraw, F Moghadam, Y Tan… - Cell systems, 2021 - cell.com
Pluripotent stem cell (PSC)-derived organoids have emerged as novel multicellular models
of human tissue development but display immature phenotypes, aberrant tissue fates, and a …

Cerebral organoids transplantation repairs infarcted cortex and restores impaired function after stroke

SY Cao, D Yang, ZQ Huang, YH Lin, HY Wu… - NPJ Regenerative …, 2023 - nature.com
Stroke usually causes prolonged or lifelong disability, owing to the permanent loss of
infarcted tissue. Although a variety of stem cell transplantation has been explored to improve …

Advancing drug discovery for neurological disorders using iPSC-derived neural organoids

G Costamagna, GP Comi, S Corti - International Journal of Molecular …, 2021 - mdpi.com
In the last decade, different research groups in the academic setting have developed
induced pluripotent stem cell-based protocols to generate three-dimensional, multicellular …

Unlocking neural function with 3D in vitro models: A technical review of self-assembled, guided, and bioprinted brain organoids and their applications in the study of …

C D'Antoni, L Mautone, C Sanchini, L Tondo… - International Journal of …, 2023 - mdpi.com
Understanding the complexities of the human brain and its associated disorders poses a
significant challenge in neuroscience. Traditional research methods have limitations in …