Microfluidics for neuronal cell and circuit engineering
The widespread adoption of microfluidic devices among the neuroscience and neurobiology
communities has enabled addressing a broad range of questions at the molecular, cellular …
communities has enabled addressing a broad range of questions at the molecular, cellular …
Generating and using transcriptomically based retinal cell atlases
It has been known for over a century that the basic organization of the retina is conserved
across vertebrates. It has been equally clear that retinal cells can be classified into …
across vertebrates. It has been equally clear that retinal cells can be classified into …
Functional neuronal circuitry and oscillatory dynamics in human brain organoids
T Sharf, T Van Der Molen, SMK Glasauer… - Nature …, 2022 - nature.com
Human brain organoids replicate much of the cellular diversity and developmental anatomy
of the human brain. However, the physiology of neuronal circuits within organoids remains …
of the human brain. However, the physiology of neuronal circuits within organoids remains …
Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology
Microglia play critical roles in brain development, homeostasis, and disease. Microglia in
animal models cannot accurately model human microglia due to notable transcriptomic and …
animal models cannot accurately model human microglia due to notable transcriptomic and …
[HTML][HTML] Extension of retinofugal projections in an assembled model of human pluripotent stem cell-derived organoids
CM Fligor, SS Lavekar, J Harkin, PK Shields… - Stem Cell Reports, 2021 - cell.com
The development of the visual system involves the coordination of spatial and temporal
events to specify the organization of varied cell types, including the elongation of axons from …
events to specify the organization of varied cell types, including the elongation of axons from …
Microplastics exposure affects neural development of human pluripotent stem cell-derived cortical spheroids
Plastics have been part of our ecosystem for about a century and their degradation by
different environmental factors produce secondary microplastics (MPs). To date, the impact …
different environmental factors produce secondary microplastics (MPs). To date, the impact …
[HTML][HTML] Gene regulatory network analysis and engineering directs development and vascularization of multilineage human liver organoids
Pluripotent stem cell (PSC)-derived organoids have emerged as novel multicellular models
of human tissue development but display immature phenotypes, aberrant tissue fates, and a …
of human tissue development but display immature phenotypes, aberrant tissue fates, and a …
Cerebral organoids transplantation repairs infarcted cortex and restores impaired function after stroke
SY Cao, D Yang, ZQ Huang, YH Lin, HY Wu… - NPJ Regenerative …, 2023 - nature.com
Stroke usually causes prolonged or lifelong disability, owing to the permanent loss of
infarcted tissue. Although a variety of stem cell transplantation has been explored to improve …
infarcted tissue. Although a variety of stem cell transplantation has been explored to improve …
Advancing drug discovery for neurological disorders using iPSC-derived neural organoids
G Costamagna, GP Comi, S Corti - International Journal of Molecular …, 2021 - mdpi.com
In the last decade, different research groups in the academic setting have developed
induced pluripotent stem cell-based protocols to generate three-dimensional, multicellular …
induced pluripotent stem cell-based protocols to generate three-dimensional, multicellular …
Unlocking neural function with 3D in vitro models: A technical review of self-assembled, guided, and bioprinted brain organoids and their applications in the study of …
C D'Antoni, L Mautone, C Sanchini, L Tondo… - International Journal of …, 2023 - mdpi.com
Understanding the complexities of the human brain and its associated disorders poses a
significant challenge in neuroscience. Traditional research methods have limitations in …
significant challenge in neuroscience. Traditional research methods have limitations in …