Biological activities of ruthenium NHC complexes: An update
A Catalano, A Mariconda, MS Sinicropi, J Ceramella… - Antibiotics, 2023 - mdpi.com
Ruthenium N-heterocyclic carbene (NHC) complexes have unique physico-chemical
properties as catalysts and a huge potential in medicinal chemistry and pharmacology …
properties as catalysts and a huge potential in medicinal chemistry and pharmacology …
Combination of ruthenium (II) polypyridyl complex Δ-Ru1 and Taxol enhances the anti-cancer effect on Taxol-resistant cancer cells through Caspase-1/GSDMD …
D Chen, S Guo, X Tang, Y Rong, H Bo, H Shen… - Journal of Inorganic …, 2022 - Elsevier
Taxol is the first-line drug for cancer treatment. However, tumor resistance to Taxol is still a
significant challenge in clinical practice. Here, we studied the synergistic effect of a …
significant challenge in clinical practice. Here, we studied the synergistic effect of a …
Development of rGO/RuO2 nanocomposite for voltammetric sensors, dye degradation and antioxidant studies
M Mylarappa, S Chandruvasan, R Sandhya - Materials Chemistry and …, 2024 - Elsevier
The current study shows the synthesis of reduced graphene incorporated ruthenium oxide
(rGO/RuO 2) using a reflux approach. The rGO/RuO 2 nanocomposite was confirmed using …
(rGO/RuO 2) using a reflux approach. The rGO/RuO 2 nanocomposite was confirmed using …
New nanostructured materials based on mesoporous silica loaded with Ru (II)/Ru (III) complexes with anticancer and antimicrobial properties
A new series of nanostructured materials was obtained by functionalization of SBA-15
mesoporous silica with Ru (II) and Ru (III) complexes bearing Schiff base ligands derived …
mesoporous silica with Ru (II) and Ru (III) complexes bearing Schiff base ligands derived …
Ruthenium complexes bearing glucosyl ligands are able to inhibit the amyloid aggregation of short histidine-peptides
D Florio, S La Manna, A Annunziata, I Iacobucci… - Dalton …, 2023 - pubs.rsc.org
Neurodegenerative diseases are often characterized by the formation of aggregates of
amyloidogenic peptides and proteins, facilitating the formation of neurofibrillary plaques. In …
amyloidogenic peptides and proteins, facilitating the formation of neurofibrillary plaques. In …
Cancer cell extravasation requires iplectin-mediated delivery of MT1-MMP at invadopodia
OR Grafinger, JJ Hayward, Y Meng… - British Journal of …, 2024 - nature.com
Background Invadopodia facilitate cancer cell extravasation, but the molecular mechanism
whereby invadopodia-specific proteases such as MT1-MMP are called to invadopodia is …
whereby invadopodia-specific proteases such as MT1-MMP are called to invadopodia is …
Copper (II) cation and bathophenanthroline coordination enhance therapeutic effects of naringenin against lung tumor cells
JY Caro-Ramirez, MG Rivas, PJ Gonzalez… - BioMetals, 2022 - Springer
The development of new anticancer compounds is one of the challenges of bioinorganic
and medicinal chemistry. Naringenin and its metal complexes have been recognized as …
and medicinal chemistry. Naringenin and its metal complexes have been recognized as …
[HTML][HTML] Lead to hit ruthenium-cyclopentadienyl anticancer compounds: Cytotoxicity against breast cancer cells, metabolic stability and metabolite profiling
I Maximiano, C Henriques, RG Teixeira… - Journal of Inorganic …, 2024 - Elsevier
The successful choice of hit compounds during drug development programs involves the
integration of structure-activity relationship (SAR) studies with pharmacokinetic …
integration of structure-activity relationship (SAR) studies with pharmacokinetic …
Red-Light-Responsive Polypeptoid Nanoassemblies Containing a Ruthenium (II) Polypyridyl Complex with Synergistically Enhanced Drug Release and ROS …
Polymer micelles/vesicles made of a red-light-responsive Ru (II)-containing block copolymer
(PolyRu) are elaborated as a model system for anticancer phototherapy. PolyRu is …
(PolyRu) are elaborated as a model system for anticancer phototherapy. PolyRu is …
Necroptosis induced by ruthenium (II) complexes as mitochondrial disruptors
J Gonçalves, JD Amaral, R Capela, MJ Perry… - Cell Death …, 2024 - nature.com
Inducing necroptosis in cancer cells has emerged as an effective strategy to overcome drug
resistance. However, while organic small molecules have been extensively studied for this …
resistance. However, while organic small molecules have been extensively studied for this …