Oxidatively induced DNA damage is caused in living organisms by endogenous and
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …

First discovered as a structure-specific endonuclease that evolved to cut at the base of
single-stranded flaps, flap endonuclease (FEN1) is now recognized as a central component …

Abstract 'Every Hour Hurts, The Last One Kills'. That is an old saying about getting old. Every
day, thousands of DNA damaging events take place in each cell of our body, but efficient …

We used CDK4/hTERT–immortalized normal human bronchial epithelial cells (HBEC) from
several individuals to study lung cancer pathogenesis by introducing combinations of …

Abstract Flap endonuclease-1 (FEN1) is a member of the Rad2 structure-specific nuclease
family. FEN1 possesses FEN, 5′-exonuclease and gap-endonuclease activities. The …

We evaluated the contribution of three genetic alterations (p53 knockdown, K-RASV12, and
mutant EGFR) to lung tumorigenesis using human bronchial epithelial cells (HBEC) …

The observation that mutations in tumor suppressor genes can have haploinsufficient, as
well as gain of function and dominant negative, phenotypes has caused a reevaluation of …

FEN1 has key roles in Okazaki fragment maturation during replication, long patch base
excision repair, rescue of stalled replication forks, maintenance of telomere stability and …

Purpose: Gastric cancer is one of the most frequently diagnosed malignancies in the world,
especially in Korea and Japan. To understand the molecular mechanism associated with …

Abstract Flap endonuclease 1 (FEN1) is a structure-specific nuclease best known for its
critical roles in Okazaki fragment maturation, DNA repair, and apoptosis-induced DNA …