Circular RNAs (circRNAs) are a very interesting class of conserved single-stranded RNA
molecules derived from exonic or intronic sequences by precursor mRNA back-splicing …

Gastric cancer is the fourth most common malignancy and the third leading cause of cancer-
related deaths worldwide. Advanced gastric cancer patients can notably benefit from …

To date, thousands of highly abundant and conserved single-stranded RNA molecules
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …

ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally
and mechanistically distinct substrates against steep concentration gradients. Among the …

As the standard treatments for cancer, chemotherapy and radiotherapy have been widely
applied to clinical practice worldwide. However, the resistance to cancer therapies is a major …

Circular RNAs (circRNAs), one type of non-coding RNA, were initially misinterpreted as
nonfunctional products of pre-mRNA mis-splicing. Currently, circRNAs have been proven to …

Acute myeloid leukemia (AML) is a malignant tumor of the immature myeloid hematopoietic
cells in the bone marrow (BM). It is a highly heterogeneous disease, with rising morbidity …

Targeted treatment, which can specifically kill tumour cells without affecting normal cells, is a
new approach for tumour therapy. However, tumour cells tend to acquire resistance to …

Drug resistance is a major hurdle in cancer treatment and a key cause of poor prognosis.
Epitranscriptomics and epiproteomics are crucial in cell proliferation, migration, invasion …

CircRNAs are a novel class of RNA molecules with a unique closed continuous loop
structure. CircRNAs are abundant in eukaryotic cells, have unique stability and tissue …