Renal fibrosis is the expected outcome of many chronic kidney diseases, and effective
treatments are needed. Emodin (EMO) and tanshinone IIA (Tan IIA) are active ingredients in …

Oral administration is the most preferred and simplest route, but it is highly challenging due
to the numerous barriers in the gastrointestinal tract. To overcome these barriers …

In this review, we will discuss the current status of extracellular vesicle (EV) delivery via
biopolymeric scaffolds for therapeutic applications and the challenges associated with the …

The gastrointestinal system, often regarded as the'second brain of humanity,'maintains a
profound connection with the cerebral realm. Unlocking the intricate metabolic pathways of …

Wall material types influence the efficacy of nanocarriers in oral delivery systems. We
utilized three food biomacromolecules (whey protein isolate, oxidized starch, lipids) to …

The gastrointestinal (GI) tract's mucus layer serves as a critical barrier and a mediator in
drug nanoparticle delivery. The mucus layer's diverse molecular structures and spatial …

Insulin, a pivotal anabolic hormone, regulates glucose homeostasis by facilitating the
conversion of blood glucose to energy or storage. Dysfunction in insulin activity, often …

Mucus penetration is one of the physiologic barriers of inhalation and nanocarriers can
effectively facilitate the permeation of drugs. The interactions between the nanocarriers and …

Although the importance of quercetin (QUE) in diets and as food supplements is well-known,
the oral utilization of QUE is limited by its instability, poor solubility, and low bioavailability …

To improve the oral absorption and anticancer efficacy of the BCS-IV drug etoposide (ETO),
oral nanocrystal-loaded lipid carriers (Lipo@ NCs) were developed in this study by …