Methods A systematic search was conducted using the Medline® and Embase® databases
up to 30 June 2017 employing specific medical subject heading terms. Additionally, the …

Introduction: The approval of several biosimilars in the past years has prompted discussion
on potential safety risks associated with switching to and from these products. It has been …

Abstract mPEG-PLA and PLA-PEG-PLA copolymeric nanoparticles with three different PLA
to PEG ratios are synthesized and used for encapsulation of recombinant human Growth …

A hyaluronic acid‐based anionic nanogel formed by self‐assembly of cholesteryl‐group‐
bearing HA is designed for protein delivery. The HA nanogel spontaneously binds various …

Isolated growth hormone deficiency is the most common pituitary hormone deficiency and
can result from congenital or acquired causes, although the majority of cases are idiopathic …

The availability of synthetic recombinant human growth hormone (GH) in potentially
unlimited quantities since the 1980s has improved understanding of the many nonstatural …

Background: In most cases, the growth hormone stimulation test is a necessary component
for the diagnosis of growth hormone deficiency (GHD) in children. Diagnostic testing can …

Growth hormone (GH) treatment has been an established therapy for GH deficiency (GHD)
in children and adults for more than three decades. Numerous studies have shown that GH …

LAGH will represent an advancement over daily recombinant human GH injections because
of fewer injections that may offer increased acceptance, tolerability, and therapeutic flexibility …

Objective Recombinant human growth hormone (rhGH) replacement therapy in children
generally requires daily subcutaneous (sc) injections, which may be inconvenient for …