Echocardiographic strain analysis for the early detection of left ventricular systolic/diastolic dysfunction and dyssynchrony in a mouse model of physiological aging
Heart disease is the leading cause of hospitalization and death worldwide, severely
affecting health care costs. Aging is a significant risk factor for heart disease, and the …
affecting health care costs. Aging is a significant risk factor for heart disease, and the …
Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure
Heart failure (HF) is characterized by poor survival, a loss of catecholamine reserve and
cellular structural remodeling in the form of disorganization and loss of the transverse tubule …
cellular structural remodeling in the form of disorganization and loss of the transverse tubule …
Increased Ca buffering underpins remodelling of Ca2+ handling in old sheep atrial myocytes
JD Clarke, JL Caldwell, CM Pearman… - The Journal of …, 2017 - Wiley Online Library
Key points Ageing is associated with an increased risk of cardiovascular disease and
arrhythmias, with the most common arrhythmia being found in the atria of the heart. Little is …
arrhythmias, with the most common arrhythmia being found in the atria of the heart. Little is …
Atrial t-tubules adopt a specialist developmental state while alterations to Ca2+ buffering maintain systolic Ca2+ during postnatal development
CER Smith, JD Clarke, CJ Quinn, Z Sultan, H Najem… - bioRxiv, 2023 - biorxiv.org
Transverse (t)-tubules ensure a uniform rise in calcium (Ca2+) and thus contraction in
cardiac cells. Though more extensively studied in the ventricle, t-tubules also play a key role …
cardiac cells. Though more extensively studied in the ventricle, t-tubules also play a key role …
Neuronal cholinergic signaling constrains norepinephrine activity in the heart
DA Guimarães, NSS Aquino… - … of Physiology-Cell …, 2022 - journals.physiology.org
It is well known that cholinergic hypofunction contributes to cardiac pathology, yet, the
mechanisms involved remain unclear. Our previous study has shown that genetically …
mechanisms involved remain unclear. Our previous study has shown that genetically …
Chronic vagal nerve stimulation has no effect on tachycardia‐induced heart failure progression or excitation–contraction coupling
EJ Radcliffe, CM Pearman, A Watkins… - Physiological …, 2020 - Wiley Online Library
Autonomic dysregulation plays a key role in the development and progression of heart
failure (HF). Vagal nerve stimulation (VNS) may be a promising therapeutic approach …
failure (HF). Vagal nerve stimulation (VNS) may be a promising therapeutic approach …
[图书][B] Plasma Cytokines and Markers of Remodeling in Myocardial Injury and Repair
PS Chaggar - 2018 - search.proquest.com
Introduction: The heart failure (HF) phenotype is associated with multiple pathological
changes at the cellular/biochemical level but this is not always a permanent state, despite …
changes at the cellular/biochemical level but this is not always a permanent state, despite …
[PDF][PDF] PDE5 inhibition improves symptom-free survival and restores transverse tubule loss and catecholamine responsiveness in heart failure
M Lawless, JL Caldwell, EJ Radcliffe, GWP Madders… - 2018 - scholar.archive.org
Heart failure is characterized by poor survival, a loss of catecholamine reserve and cellular
structural remodeling in the form of disorganization and loss of the transverse tubule …
structural remodeling in the form of disorganization and loss of the transverse tubule …