The mammalian lung´ s structural design is optimized to serve its main function: gas
exchange. It takes place in the alveolar region (parenchyma) where air and blood are …

Pulmonary surfactant is a critical component of lung function in healthy individuals. It
functions in part by lowering surface tension in the alveoli, thereby allowing for breathing …

Electronic nicotine delivery systems (ENDS) or e-cigarettes have emerged as a popular
recreational tool among adolescents and adults. Although the use of ENDS is often …

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is linked to a
respiratory syndrome with altered pulmonary and alveolar function that can lead to acute …

Pulmonary administration route has been extensively exploited for the treatment of local
lung diseases such as asthma, chronic obstructive pulmonary diseases and respiratory …

The respiratory surface in the mammalian lung is stabilized by pulmonary surfactant, a
membrane-based system composed of multiple lipids and specific proteins, the primary …

Organs-on-chips have the potential to improve drug development efficiency and decrease
the need for animal testing. For the successful integration of these devices in research and …

Phosphatidylcholine (PC) is the major phospholipid component of all plasma lipoprotein
classes. PC is the only phospholipid which is currently known to be required for lipoprotein …

The lung interfaces with the environment across a continuous epithelium composed of
various cell types along the proximal and distal airways. At the alveolar structure level, the …

Pulmonary surfactant is an essential lipid–protein complex to maintain an operative
respiratory surface at the mammalian lungs. It reduces surface tension at the alveolar air …