The vascular endothelium is a dynamic, functionally complex organ, modulating multiple
biological processes, including vascular tone and permeability, inflammatory responses …

The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Endothelial nitric oxide synthase (eNOS) plays a critical role in regulating and maintaining a
healthy cardiovascular system. The importance of eNOS can be emphasized from the …

As the first discovered gaseous signaling molecule, nitric oxide (NO) affects a number of
cellular processes, including those involving vascular cells. This brief review summarizes …

Single dose administration of dietary inorganic nitrate acutely reduces blood pressure (BP)
in normotensive healthy volunteers, via bioconversion to the vasodilator nitric oxide. We …

In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …

Twenty years have passed since Brownlee and colleagues proposed a single unifying
mechanism for diabetic complications, introducing a turning point in this field of research …

Reduced nitric oxide bioavailability contributes to endothelial dysfunction and hypertension.
The endothelial isoform of nitric oxide synthase (eNOS) is responsible for the production of …

Nitric oxide (NO) has long been known as endothelium-derived relaxing factor. It is a
vasodilator, modulating vascular tone, blood pressure and hemodynamics, a role exploited …

Coronary microvascular disease (CMD), which affects the arterioles and capillary
endothelium that regulate myocardial perfusion, is an increasingly recognized source of …