The cell cycle of eukaryotic cells varies greatly from species to species and tissue to tissue.
Since an erroneous control of the cell cycle can have disastrous consequences for cellular …

Complexes consisting of cyclin‐dependent kinases (CDKs) and their regulatory subunits
(the cyclins) control the progression of normal mammalian cells through the cell cycle …

Aberrant CDK5 activity is implicated in a number of neurodegenerative disorders. Isoflurane
exposure leads to neuronal apoptosis, and subsequent learning and memory defects in the …

A series of adenosine derivatives bearing a boron cluster were synthesized and evaluated
for their cytotoxicity against primary peripheral mononuclear cells from the blood of 17 …

Chronic lymphocytic leukemia (CLL) is a heterogenous disease with an imbalance between
apoptosis and cell proliferation. Therefore, the main goal in CLL therapy is to induce …

Introduction: The progression of the mammalian cell cycle is driven by the transient
activation of complexes consisting of cyclins and cyclin-dependent kinases (CDKs). Loss of …

Human MCF‐7 breast cancer cells are resistant to pro‐apoptotic stimuli due to caspase‐3
inactivation. On the other hand, they should be sensitive to agents like selective …

KCl withdrawal-induced apoptosis in cerebellar granule neurons is associated with aberrant
cell cycle activation, and treatment with cyclin-dependent kinase (Cdk) inhibitors protects …

The deregulation of apoptosis and the cell cycle are important steps in the onset of cancer,
giving cells unlimited reproductive potential and increasing their likelihood of survival. The …

To improve the efficacy of therapeutic options in chronic lymphocytic leukemia (CLL) an in
vitro system to determine the response of mononuclear blood cells from blood of patients …