PD-L1, frequently expressed in human cancers, engages with PD-1 on immune cells and
contributes to cancer immune evasion. As such, antibodies blocking the PD-1/PD-L1 …

Selective tyrosine kinase inhibitors have emerged as important therapeutic agents in the
treatment of a variety of human malignancies. Although several of these inhibitors have …

Accumulating evidence suggests important roles for the receptor tyrosine kinase Axl in
cancer progression, invasion, metastasis, drug resistance, and patient mortality, highlighting …

Background: Knowledge of radiobiology is of paramount importance to be able to grasp and
have an in-depth understanding of the consequences of ionizing radiation. One of the most …

More than 500 compounds chosen to represent kinase inhibitor space have been screened
against a panel of over 200 protein kinases. Significant results include the identification of …

Since the first approval of a protein kinase inhibitor (PKI) by the Food and Drug
Administration (FDA) in 2001, 55 new PKIs have reached the market, and many inhibitors …

The development of drug resistance and severe side-effects has reduced the clinical efficacy
of the existing anti-cancer drugs available in the market. Thus, there is always a constant …

The protein kinase family, one of the largest gene families in eukaryotes, plays an important
role in regulating various cellular processes such as cell proliferation, cell death, cell cycle …

In developing inhibitors of the LIM kinases, the initial lead molecules combined potent target
inhibition with potent cytotoxic activity. However, as subsequent compounds were evaluated …

Purpose: Chondrosarcomas are notoriously resistant to cytotoxic chemotherapeutic agents.
We sought to identify critical signaling pathways that contribute to their survival and …