Oncogenesis in breast cancer often requires the overexpression of the nuclear receptor
coactivator AIB1/SRC-3 acting in conjunction with estrogen receptor-α (ERα) …

Simple Summary Recent research has revealed a possible synergy between kinase
inhibitors and immunotherapy in the treatment of breast cancer. Kinase inhibitors can …

Abstract Ethnopharmacological relevence Mangifera zeylanica Hook. f.(Anacardiaceae) is a
plant endemic to Sri Lanka. Its bark has been used in traditional and Ayurvedic medicine for …

We previously showed that integrin αvβ3 overexpression and engagement by its ligand
vitronectin increased adhesion, motility, and proliferation of human ovarian cancer cells. In …

The electrochemical oxidation mechanism of the anticancer drug and kinases inhibitor
dasatinib was studied by cyclic, differential pulse and square wave voltammetry using a …

Malaria remains a major killer in many parts of the world. Recently, the development of
nonprofit organisations aimed at fighting this deadly scourge incited academic and industrial …

Human lemur tyrosine kinase-3 (LMTK3) is an oncogenic kinase known to regulate ER-α
through phosphorylation and is considered to be a novel therapeutic target for breast …

With ongoing resistance problems against the marketed EGFR inhibitors having a
quinazoline core scaffold there is a need for the development of novel inhibitors having a …

The alterations in the expression patterns of protein kinases often implicate human cancer
initiation and progression. Human tousled-like kinases (TLKs), both TLK1/1B and TLK2, are …

Aim: A series of benzylidene-and phenylethylidene-substituted acridone-2-carbohydrazide
derivatives were designed, synthesized and evaluated for their cytotoxicity and response to …