Abstract Epstein–Barr virus (EBV)‐associated gastric cancer (EBVaGC) is regarded as the
most prevalent malignant tumor triggered by EBV infection. In recent years, increasing …

Natural killer (NK) cells and CD8+ T cells can clear infected and transformed cells and
generate tolerance to themselves, which also prevents autoimmune diseases. Natural killer …

T cell receptors (TCRs) bind complexes of cognate major histocompatibility complex (MHC)
and peptide at relatively low affinities (1–200 μM). Nevertheless, TCR-MHC-peptide …

Multiple cell-autonomous mechanisms exist in complex metazoans to resist oncogenic
transformation, including a variety of tumor-suppressor pathways that control cell …

NKG2D is an activating immunoreceptor, first recognized on NK cells but subsequently
found on γδ T cells, CD8+ αβ T cells and macrophages. In NK cells, inhibitory signals are …

The human C-type lectin-like molecule CLEC-2 is expressed on the surface of platelets and
signaling through CLEC-2 causes platelet activation and aggregation. CLEC-2 is a receptor …

Cardiovascular homeostasis and blood pressure regulation are reliant, in part, on
interactions between natriuretic peptide (NP) hormones and natriuretic peptide receptors …

The activating immunoreceptor NKG2D promotes elimination of infected or malignant cells
by cytotoxic lymphocytes through engagement of stress-induced MHC class I-related …

Breast cancer (BC) remains as one of the important causes of cancer deaths among women
globally. Therefore, finding an effective treatment for BC is really needed. Cancer …

Background One of the mechanisms by which tumors evade immune surveillance is through
shedding of the major histocompatibility complex (MHC) class I chain-related protein A and …