COPD is now widely recognized as a complex heterogeneous syndrome, having both
pulmonary and extrapulmonary features. In clinical practice, the diagnosis of COPD is based …

Versican is a proteoglycan that has many different roles in tissue homeostasis and
inflammation. The biochemical structure comprises four different types of the core protein …

Purpose To compare hyperpolarized helium‐3 (3He) and xenon‐129 (129Xe) MRI in
asthmatics before and after salbutamol inhalation. Materials and Methods Seven asthmatics …

Background There is a paucity of studies comparing asthma and chronic obstructive
pulmonary disease (COPD) based on thoracic quantitative computed tomographic (QCT) …

Background Fixed airflow obstruction (FAO) in asthma, particularly in nonsmokers, is
generally believed to be caused by airway remodeling. However, parenchymal destruction …

BACKGROUND: Exacerbations of asthma are thought to be caused by airflow obstruction
resulting from airway inflammation, bronchospasm, and mucus plugging. Histologic …

Background Small airway remodeling is the cardinal feature underlying chronic airway
diseases. There is no modality which identifies small airway pathological changes, which is …

Recently, the therapeutic potential of immune-modulation during the progression of chronic
obstructive pulmonary disease (COPD) has been attracting increasing interest. However …

Background Quantitative measurement of airway dimensions using computed tomography
(CT) is performed in relatively larger airways due to the limited resolution of CT scans …

Overlap of asthma and COPD has attracted attention recently. We aimed to clarify
physiological and morphological differences of the airways between COPD and asthma …