miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis

CE Condrat, DC Thompson, MG Barbu, OL Bugnar… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) represent a class of small, non-coding RNAs with the main roles of
regulating mRNA through its degradation and adjusting protein levels. In recent years …

Circulating cell-free nucleic acids: characteristics and applications

O Pös, O Biró, T Szemes, B Nagy - European Journal of Human …, 2018 - nature.com
Liquid biopsy is becoming a very popular sample obtaining procedure, replacing the
invasive sampling methods for the diagnostic protocols. The advantages of this method …

miRTarBase 2020: updates to the experimentally validated microRNA–target interaction database

HY Huang, YCD Lin, J Li, KY Huang… - Nucleic acids …, 2020 - academic.oup.com
MicroRNAs (miRNAs) are small non-coding RNAs (typically consisting of 18–25
nucleotides) that negatively control expression of target genes at the post-transcriptional …

Detection of circulating miRNAs: comparative analysis of extracellular vesicle-incorporated miRNAs and cell-free miRNAs in whole plasma of prostate cancer patients

E Endzeliņš, A Berger, V Melne, C Bajo-Santos… - BMC cancer, 2017 - Springer
Background Circulating cell-free miRNAs have emerged as promising minimally-invasive
biomarkers for early detection, prognosis and monitoring of cancer. They can exist in the …

[HTML][HTML] Recent progress on liquid biopsy analysis using surface-enhanced Raman spectroscopy

Y Zhang, X Mi, X Tan, R Xiang - Theranostics, 2019 - ncbi.nlm.nih.gov
Traditional tissue biopsy is limited in understanding heterogeneity and dynamic evolution of
tumors. Instead, analyzing circulating cancer markers in various body fluids, commonly …

The liquid biopsy in the management of colorectal cancer patients: Current applications and future scenarios

N Normanno, A Cervantes, F Ciardiello… - Cancer treatment …, 2018 - Elsevier
The term liquid biopsy refers to the analysis of biomarkers in any body fluid, including blood,
urine and cerebrospinal fluid. In cancer, liquid biopsy testing allows the analysis of tumor …

Molecular mechanisms of epithelial to mesenchymal transition in tumor metastasis

A Nieszporek, K Skrzypek, G Adamek… - Acta Biochimica …, 2019 - ruj.uj.edu.pl
Epithelial to mesenchymal transition (EMT) is a process where cancer cells lose their
epithelial features, the cytoskeletal architecture is re-organized, the cell shape changes and …

Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs

J Karttunen, M Heiskanen… - Journal of …, 2019 - Taylor & Francis
The microRNA (miRNA) cargo contained in plasma extracellular vesicles (EVs) offers a
relatively little explored source of biomarkers for brain diseases that can be obtained …

Cold-activated brown fat-derived extracellular vesicle-miR-378a-3p stimulates hepatic gluconeogenesis in male mice

J Xu, L Cui, J Wang, S Zheng, H Zhang, S Ke… - Nature …, 2023 - nature.com
During cold exposure, activated brown adipose tissue (BAT) takes up a large amount of
circulating glucose to fuel non-shivering thermogenesis and defend against hypothermia …

Non-nutritive sweeteners and their implications on the development of metabolic syndrome

I Liauchonak, B Qorri, F Dawoud, Y Riat, MR Szewczuk - Nutrients, 2019 - mdpi.com
Individuals widely use non-nutritive sweeteners (NNS) in attempts to lower their overall daily
caloric intake, lose weight, and sustain a healthy diet. There are insufficient scientific data …