Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM) are common
conditions that regularly co-exist and can act synergistically to drive adverse outcomes. The …

The merits of a fibre‐rich diet are well documented. Resistant starch (RS) is a form of starch
that resists digestion in the small intestine and, as such, is classified as a type of dietary …

Body fat mass increases when energy intake exceeds energy expenditure. In the long term,
a positive energy balance will result in obesity. The worldwide prevalence of obesity has …

Abstract Purpose of Review Obesity is a global health crisis with detrimental effects on all
organ systems leading to worsening disease state and rising costs of care. Persons with …

We have greatly advanced our ability to grow a diverse range of tissue-derived and
pluripotent stem cell–derived gastrointestinal (GI) tissues in vitro. These systems, broadly …

Diabetes is a growing global health concern, as is obesity. Diabetes and obesity are
intrinsically linked: obesity increases the risk of diabetes and also contributes to disease …

Over a relatively short period, obesity and type 2 diabetes have come to represent a large
medical and economic burden to global societies. The epidemic rise in the prevalence of …

Abstract Glucagonlike peptide 1 (GLP-1) receptor agonists have been efficacious for the
treatment of type 2 diabetes due to their ability to reduce weight and attenuate …

Abstract Purpose of Review This review provides an update on the role of gut hormones and
their interactions in the regulation of energy homeostasis, describes gut hormone …

Chemical derivatives of the gut-derived peptide hormone glucagon-like peptide 1 (GLP-1)
are among the best-in-class pharmacotherapies to treat obesity and type 2 diabetes …