The immune system is a fascinating world of cells, soluble factors, interacting cells, and
tissues, all of which are interconnected. The highly complex nature of the immune system …

Human inborn errors of immunity (IEI) are a group of 485 distinct genetic disorders affecting
children and adults. Signs and symptoms of IEI are heterogeneous, and accurate diagnosis …

Introduction: The German PID-NET registry was founded in 2009, serving as the first national
registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the …

Background The number of inherited diseases and the spectrum of clinical manifestations of
primary immunodeficiency disorders (PIDs) are ever-expanding. Molecular diagnosis using …

Severe combined immunodeficiency disease (SCID) is the most severe form of primary
immunodeficiency disorders (PID). T-cell receptor excision circle (TREC) copy number …

Guidelines for screening for primary immunodeficiencies (PID) are well-defined and several
consensus diagnostic strategies have been proposed. These consensus proposals have …

Monogenic immune dysregulation diseases (MIDD) are caused by defective
immunotolerance. This study was designed to increase knowledge on the prevalence and …

Update on Immunodeficiency-Associated Vaccine-Derived Polioviruses — Worldwide, July
2018–December 2019 | MMWR Skip directly to site content Skip directly to page options Skip …

Newborn screening (NBS) programs continue to expand due to innovations in both test
methods and treatment options. Since the introduction of the T-cell receptor excision circle …

Objective Inborn errors of immunity (IEI) are rare genetic conditions affecting the immune
system. The rate of IEI and their presentation, course, and treatment are all affected by a …