Anticancer potential of the plant‐derived Saponin Gracillin: a comprehensive review of mechanistic approaches

MS Bhuia, R Chowdhury, FA Sonia… - Chemistry & …, 2023 - Wiley Online Library
With the increasing prevalence of cancer and the toxic side effects of synthetic drugs, natural
products are being developed as promising therapeutic approaches. Gracillin is a naturally …

Hydrogel systems for targeted cancer therapy

X Li, X Xu, M Xu, Z Geng, P Ji, Y Liu - Frontiers in Bioengineering and …, 2023 - frontiersin.org
When hydrogel materials with excellent biocompatibility and biodegradability are used as
excellent new drug carriers in the treatment of cancer, they confer the following three …

TTD: Therapeutic Target Database describing target druggability information

Y Zhou, Y Zhang, D Zhao, X Yu, X Shen… - Nucleic acids …, 2024 - academic.oup.com
Target discovery is one of the essential steps in modern drug development, and the
identification of promising targets is fundamental for developing first-in-class drug. A variety …

[HTML][HTML] Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma

Y Zhu, X Jian, S Chen, G An, D Jiang, Q Yang, J Zhang… - Cell Metabolism, 2024 - cell.com
The gut microbiome has been found to play a crucial role in the treatment of multiple
myeloma (MM), which is still considered incurable due to drug resistance. In previous …

Role of gut microbiome in cancer immunotherapy: from predictive biomarker to therapeutic target

M Zhang, J Liu, Q Xia - Experimental Hematology & Oncology, 2023 - Springer
Immunotherapy has emerged as an effective treatment for various types of cancers. Recent
studies have highlighted a significant correlation between the gut microbiome and patients' …

Nano-enabled colorectal cancer therapy

Q Pan, X Fan, L Xie, D Wu, R Liu, W Gao, K Luo… - Journal of Controlled …, 2023 - Elsevier
Colorectal cancer (CRC), one of the most common and deadliest diseases worldwide, poses
a great health threat and social burden. The clinical treatments of CRC encompassing …

The evolving landscape of fecal microbial transplantation

T Shao, R Hsu, C Hacein-Bey, W Zhang, L Gao… - Clinical Reviews in …, 2023 - Springer
The human gastrointestinal tract houses an enormous microbial ecosystem. Recent studies
have shown that the gut microbiota plays significant physiological roles and maintains …

A rodent model of human-dose-equivalent 5-fluorouracil: toxicity in the liver, kidneys, and lungs

MC da Silva, LC Fabiano, KC da Costa Salomão… - Antioxidants, 2023 - mdpi.com
5-Fluorouracil (5-FU) is a chemotherapy drug widely used to treat a range of cancer types,
despite the recurrence of adverse reactions. Therefore, information on its side effects when …

Modulating the gut microbiota by probiotics, prebiotics, postbiotics, and fecal microbiota transplantation: An emerging trend in cancer patient care

S Ciernikova, A Sevcikova, L Drgona… - Biochimica et Biophysica …, 2023 - Elsevier
Abstract Treatment resistance, together with acute and late adverse effects, represents
critical issues in the management of cancer patients. Promising results from preclinical and …

Diversification and deleterious role of microbiome in gastric cancer

I Chattopadhyay, R Gundamaraju, A Rajeev - Cancer Reports, 2023 - Wiley Online Library
Gut microbiota dictates the fate of several diseases, including cancer. Most gastric cancers
(GC) belong to gastric adenocarcinomas (GAC). Helicobacter pylori colonizes the gastric …