Effect of Surfactants, Gastric Emptying, and Dosage Form on Supersaturation of Dipyridamole in an in Vitro Model Simulating the Stomach and Duodenum
A Mitra, HM Fadda - Molecular pharmaceutics, 2014 - ACS Publications
The purpose of this study was to investigate the influence of gastric emptying patterns,
surfactants, and dosage form on the supersaturation of a poorly soluble weakly basic drug …
surfactants, and dosage form on the supersaturation of a poorly soluble weakly basic drug …
Calculation of drug-polymer mixing enthalpy as a new screening method of precipitation inhibitors for supersaturating pharmaceutical formulations
Supersaturating formulations are widely used to improve the oral bioavailability of poorly
soluble drugs. However, supersaturated solutions are thermodynamically unstable and such …
soluble drugs. However, supersaturated solutions are thermodynamically unstable and such …
Comparative Evaluation of Particle Size Reduction, Salt Formation, and Amorphous Formulation on the Biopharmaceutical Performance of a Weak Base Drug …
W Zhang, W Jia, BW Weitz, F Ma, Y Chen… - Molecular …, 2023 - ACS Publications
Various approaches have been developed to enhance the solubility or dissolution rate for
the delivery of poorly water-soluble molecules. In this work, guided by an in silico solubility …
the delivery of poorly water-soluble molecules. In this work, guided by an in silico solubility …
Selection of a water-soluble salt form of a preclinical candidate, IIIM-290: multiwell-plate salt screening and characterization
IIIM-290, a semisynthetic derivative of natural product rohitukine, is an orally bioavailable
Cdk inhibitor, efficacious in the xenograft models of colon, pancreatic, and leukemia cancer …
Cdk inhibitor, efficacious in the xenograft models of colon, pancreatic, and leukemia cancer …
Preparation and evaluation of gastro-floating hollow adhesive microspheres of carbomer/ethyl cellulose encapsulating dipyridamole
CY Zhu, JY Wang, J Huang, GH Han, YY Ji… - New Journal of …, 2019 - pubs.rsc.org
Gastro floating hollow adhesive microspheres containing dipyridamole were produced by
using an emulsion solvent evaporation method with ether and ethanol as solvent, ethyl …
using an emulsion solvent evaporation method with ether and ethanol as solvent, ethyl …
An enteric polymer mitigates the effects of gastric pH on oral absorption of poorly soluble weak acid drugs from supersaturable formulations: A case study with …
M Kataoka, R Nakanishi, M Umesaki… - European Journal of …, 2020 - Elsevier
This study demonstrated that an enteric polymer can mitigate the effects of gastric pH on the
oral absorption of a poorly water-soluble weak acid drug, dantrolene (DNT). An amorphous …
oral absorption of a poorly water-soluble weak acid drug, dantrolene (DNT). An amorphous …
Application of an in vitro dissolution/permeation system to early screening of oral formulations of poorly soluble, weakly basic drugs containing an acidic pH-modifier
M Mizoguchi, M Kataoka, K Yokoyama, R Aihara… - Journal of …, 2018 - Elsevier
This study aimed to evaluate the usefulness of the dissolution/permeation system (D/P
system) as an in vitro tool for early screening of oral formulations of weakly basic drugs …
system) as an in vitro tool for early screening of oral formulations of weakly basic drugs …
In-vitro evaluation of performance of solid immediate release dosage forms of weak bases in upper gastrointestinal lumen: experience with miconazole and …
M Dimopoulou, CS Mourouti, M Vertzoni… - Journal of Pharmacy …, 2016 - academic.oup.com
Objectives Evaluate the impact of salt and counterion identity on performance of solid
immediate release dosage forms of miconazole and clopidogrel, respectively, in fasted …
immediate release dosage forms of miconazole and clopidogrel, respectively, in fasted …
[HTML][HTML] Preparation, optimization and in vitro–in vivo investigation for capsules of the choline salt of febuxostat
X Han, W Qi, W Dong, M Guo, P Ma, J Wang - asian journal of …, 2016 - Elsevier
The objective of the present study was to exhibit the enhanced water-solubility and in vivo
oral absorption when febuxostat (FXT) became the salt formation of choline. The formation of …
oral absorption when febuxostat (FXT) became the salt formation of choline. The formation of …
双嘧达莫低共熔药物体系的筛选, 表征及性质评价
李元春， 董雪晴， 李聪伟， 安青青… - 河北大学学报(自然科学版), 2023 - xbzrb.hbu.edu.cn
采用双组分二元相图分析方法筛选难溶性药物双嘧达莫的低共熔体系, 采用差示扫描量热法(
DSC), 粉末X 线衍射(PXRD) 及傅里叶变换红外光谱(FTIR) 技术对低共熔体系进行表征 …
DSC), 粉末X 线衍射(PXRD) 及傅里叶变换红外光谱(FTIR) 技术对低共熔体系进行表征 …