Molecular genetics and diagnosis of thyroid cancer

YE Nikiforov, MN Nikiforova - Nature Reviews Endocrinology, 2011 - nature.com
Thyroid cancer is a common type of endocrine malignancy, and its incidence has been
steadily increasing in many regions of the world. Initiation and progression of thyroid cancer …

Progress in molecular-based management of differentiated thyroid cancer

M Xing, BR Haugen, M Schlumberger - The Lancet, 2013 - thelancet.com
Substantial developments have occurred in the past 5–10 years in clinical translational
research of thyroid cancer. Diagnostic molecular markers, such as RET-PTC, RAS, and …

Novel targeted therapies and immunotherapy for advanced thyroid cancers

GE Naoum, M Morkos, B Kim, W Arafat - Molecular cancer, 2018 - Springer
Thyroid cancer is a frequently encountered endocrine malignancy. Despite the favorable
prognosis of this disease, 15–20% of differentiated thyroid cancer (DTC) cases and most …

Mortality risk stratification by combining BRAF V600E and TERT promoter mutations in papillary thyroid cancer: genetic duet of BRAF and TERT promoter mutations in …

R Liu, J Bishop, G Zhu, T Zhang, PW Ladenson… - JAMA …, 2017 - jamanetwork.com
Importance BRAF V600E andTERTpromoter mutations can coexist in papillary thyroid
cancer (PTC). This genetic duet was indicated to be involved in the aggressiveness of PTC …

Senescent tumor cells lead the collective invasion in thyroid cancer

YH Kim, YW Choi, J Lee, EY Soh, JH Kim… - Nature …, 2017 - nature.com
Cellular senescence has been perceived as a barrier against carcinogenesis. However, the
senescence-associated secretory phenotype (SASP) of senescent cells can promote …

Papillary thyroid microcarcinoma: time to shift from surgery to active surveillance?

S Leboulleux, RM Tuttle, F Pacini… - The lancet Diabetes & …, 2016 - thelancet.com
The incidence of differentiated thyroid cancer is increasing greatly in high-income countries.
Roughly 50% of this increase is attributable to the identification of intrathyroidal papillary …

[HTML][HTML] Anti-tumour effects of lanreotide for pancreatic and intestinal neuroendocrine tumours: the CLARINET open-label extension study

ME Caplin, M Pavel, JB Ćwikła, AT Phan… - Endocrine-related …, 2016 - erc.bioscientifica.com
In the CLARINET study, lanreotide Autogel (depot in USA) significantly prolonged
progression-free survival (PFS) in patients with metastatic pancreatic/intestinal …

The association of the BRAFV600E mutation with prognostic factors and poor clinical outcome in papillary thyroid cancer: A meta‐analysis

TH Kim, YJ Park, JA Lim, HY Ahn, EK Lee, YJ Lee… - Cancer, 2012 - Wiley Online Library
BACKGROUND: The effects of the BRAFV600E mutation on prognostic factors and poor
clinical outcomes in papillary thyroid cancer (PTC) have not been fully quantified. The …

New developments in the diagnosis and treatment of thyroid cancer

DF Schneider, H Chen - CA: a cancer journal for clinicians, 2013 - Wiley Online Library
Answer questions and earn CME/CNE Thyroid cancer exists in several forms. Differentiated
thyroid cancers include those with papillary and follicular histologies. These tumors exist …

BRAF Mutation in Papillary Thyroid Cancer: Pathogenic Role, Molecular Bases, and Clinical Implications

M Xing - Endocrine reviews, 2007 - academic.oup.com
In recent years, the T1799A B-type Raf kinase (BRAF) mutation in thyroid cancer has
received enthusiastic investigation, and significant progress has been made toward …