New technologies for imaging molecules, particularly optical technologies, are increasingly
being used to understand the complexity, diversity and in vivo behaviour of cancers.'Omic' …

There is a wealth of new fluorescent reporter technologies for tagging of many cellular and
subcellular processes in vivo. This imposed contrast is now captured with an increasing …

Optical methods for viewing neuronal populations and projections in the intact mammalian
brain are needed, but light scattering prevents imaging deep into brain structures. We …

The zebrafish is a useful model for understanding normal and cancer stem cells, but
analysis has been limited to embryogenesis due to the opacity of the adult fish. To address …

Diffuse optical tomography, also known as near infrared tomography, has been under
investigation, for non‐invasive functional imaging of tissue, specifically for the detection and …

Heterogeneity in the differentiation behavior of hematopoietic stem cells is well documented
but poorly understood. To investigate this question at a clonal level, we isolated a …

Imaging has become an indispensable tool in the study of cancer biology and in clinical
prognosis and treatment. The rapid advances in high resolution fluorescent imaging at …

Skin‐deep: The combination of a near‐infrared fluorescent protein (iRFP) and deep‐tissue
photoacoustic tomography clearly demonstrates the superiority of iRFP over other …

Fluorescence microscopic imaging is widely used in biomedical research to study molecular
and cellular processes in cell culture or tissue samples. This is motivated by the high …

The ability to observe biological processes continuously, instead of at discrete time points,
holds great promise for the study of tissue regeneration. Ideally, single cells would be …