Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Epilepsy is a neurological disease characterized by repeated seizures. Despite of that the
brain-derived neurotrophic factor (BDNF) is implicated in the pathogenesis of …

Apolipoprotein E (APOE) is a strong genetic risk factor for late-onset Alzheimer's disease
(LOAD). APOE4 increases and APOE2 decreases risk relative to APOE3. In the P301S …

Prosaposin (PSAP) modulates glycosphingolipid metabolism and variants have been linked
to Parkinson's disease (PD). Here, we find altered PSAP levels in the plasma, CSF and post …

Progranulin (PGRN), encoded by the GRN gene in humans, was originally isolated as a
secreted growth factor that implicates in a multitude of processes ranging from regulation of …

Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal dementia (FDT) are progressive
neurodegenerative disorders that, in several cases, overlap in clinical presentation, and …

The cornea serves as a vital protective barrier for the eye; however, it is prone to injury and
damage that can disrupt corneal epithelium and nerves, triggering inflammation. Therefore …

Immune dysregulation has been identified as a critical cause of the most common types of
cardiovascular diseases (CVDs). Notably, the innate and adaptive immune responses under …

Biomarkers are molecules that can be used to observe changes in an individual's
biochemical or medical status and provide information to aid diagnosis or treatment …

Loss of function of progranulin (PGRN), encoded by the granulin (GRN) gene, is implicated
in several neurodegenerative diseases. Several therapeutics to boost PGRN levels are …