Embryonic myogenesis is a temporally and spatially regulated process that generates
skeletal muscle of the trunk and limbs. During this process, mononucleated myoblasts …

Skeletal muscle fibers are large syncytia but it is currently unknown whether gene
expression is coordinately regulated in their numerous nuclei. Here we show by snRNA-seq …

The sine oculis (SIX) family of transcription factors are key regulators of developmental
processes during embryogenesis. Members of this family control gene expression to …

The contractile properties of adult myofibers are shaped by their Myosin heavy chain isoform
content. Here, we identify by snATAC-seq a 42 kb super-enhancer at the locus regrouping …

MicroRNAs (miRs) control stem cell biology and fate. Ubiquitously expressed and conserved
miR-16 was the first miR implicated in tumorigenesis. miR-16 is low in muscle during …

The nuclei of multinucleated skeletal muscles experience substantial external force during
development and muscle contraction. Protection from such forces is partly provided by …

Background The growth and development of muscle stem cells (MuSCs) are significant
events known to affect muscle plasticity, disease, meat production, and meat quality, which …

Gravity-dependent physical processes strongly affect the ability of elderly people to maintain
musculoskeletal health by reducing muscle atrophy and increasing bone mineral density …

Four SIX homeoproteins display a combinatorial expression throughout embryonic
developmental myogenesis and they modulate the expression of the myogenic regulatory …

In mammals, adipose tissues and skeletal muscles (SkMs) play a major role in the regulation
of energy homeostasis. Recent studies point to a possibility of dynamic interplay between …