Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

Cardiac injury remains a major cause of morbidity and mortality worldwide. Despite
significant advances, a full understanding of why the heart fails to fully recover function after …

Transected axons typically fail to regenerate in the central nervous system (CNS), resulting
in chronic neurological disability in individuals with traumatic brain or spinal cord injury …

As one of the first defenders of innate immune response, neutrophils make a rapid and
robust response against infection or harmful agents. While traditionally regarded as suicidal …

In adult mammals, massive sudden loss of cardiomyocytes after infarction overwhelms the
limited regenerative capacity of the myocardium, resulting in the formation of a collagen …

Biomaterials with suitable surface modification strategies are contributing significantly to the
rapid development of the field of bone tissue engineering. Despite these encouraging …

The response of immune cells in cardiac injury is divided into three continuous phases:
inflammation, proliferation and maturation. The kinetics of the inflammatory and proliferation …

The immune system plays a central role in tissue repair and regeneration. Indeed, the
immune response to tissue injury is crucial in determining the speed and the outcome of the …

Cellular senescence is a state of irreversible cell cycle arrest associated with ageing.
Senescence of different cardiac cell types can direct the pathophysiology of cardiovascular …

The synthesis and secretion of cortisol are controlled by the hypothalamic–pituitary–adrenal
axis. Cortisol exhibits a proper 24-h circadian rhythm that affects the brain, the autonomic …