Chronic low-grade inflammation has a key role in the aging process, a state called
inflammaging. It is known that the chronic inflammatory condition generates counteracting …

Inflammatory response plays a critical role in myocardial infarction (MI) repair. The
neutrophil apoptosis and subsequent macrophage ingestion can result in inflammation …

Aims Clinical guidelines recommend early intravenous β-blockers during ongoing
myocardial infarction; however, it is unknown whether all β-blockers exert a similar …

Following acute injury, stromal cells promote tissue regeneration by a diversity of
mechanisms. Time-resolved single-cell RNA sequencing of muscle mesenchymal stromal …

Rationale: After myocardial infarction, neutrophils rapidly and massively infiltrate the heart,
where they promote both tissue healing and damage. Objective: To characterize the …

Chronic liver injury of different etiologies may result in hepatic fibrosis, a scar formation
process consisting in altered deposition of extracellular matrix. Progression of fibrosis can …

Activation of the immune system in heart failure (HF) has been recognized for over 20 years.
Initially, experimental studies demonstrated a maladaptive role of the immune system …

Tissue healing and regeneration is a complex, choreographed, spatiotemporal process
involving a plethora of cell types, the activity of which is stringently regulated in order for …

Neutrophils are key components of the innate immune system that play important roles
during infection, injury, and chronic disease. In recent years, neutrophil heterogeneity has …

Inflammation is a well‐known feature of heart failure. Studies have shown that while some
inflammation is required for repair during injury and is protective, prolonged inflammation …